Results 221 to 230 of about 323,927 (286)

DNA concentration in harvest affects retrovirus clearance capabilities of protein A chromatography

Biotechnology Progress, EarlyView.
Abstract Protein A chromatography is a key unit operation in biopharmaceutical purification, widely used to capture monoclonal antibodies (mAbs) from harvest cell culture fluid (HCCF). In addition to its primary function, protein A chromatography is also frequently tested for its ability to remove viruses. Although protein A specifically binds mAbs and
Lukas Döring, Sven Schubert, Nora Roos, Johannes Winderl, Annika Müller, Anna Ratermann, Matthias W. Kron, Jürgen Hubbuch   +7 more
wiley   +1 more source

Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis. [PDF]

J Anim Sci Biotechnol
Guo M, Zhang J, Gu S, Gao Y, Zhu Z, Zhang T, Lu H, Luo J, Zeng W.   +8 more
europepmc   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

RETRACTION: Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2. [PDF]

Cancer Sci
europepmc   +1 more source

SelO-mediated nicotinamide adenine dinucleotide hydrolysis and its implications for metabolic therapies. [PDF]

Clin Transl Med
Zhang T, Wang T, Fu Y.
europepmc   +1 more source

Lysosome‐Targeted Squaramide Anion Transporters

Chemistry – A European Journal, EarlyView.
Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo, Edward York, Anthony Thai, William G. Ryder, Daniel A. McNaughton, Philip A. Gale   +5 more
wiley   +1 more source

PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance. [PDF]

Plant J
Fernie AR, Decros G, Multhoff J, Sippel J, Niemeier JO, Barreto P, Sampathkumar A, Sonnewald U, Schwarzländer M.   +8 more
europepmc   +1 more source

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain. [PDF]

ACS Chem Biol
Bhat P, Salim H, Ritchey JL, Li N, Harty BB, Patel T, Zhao J, Wang QE, King VL, Tartaglia L, Gyuris J, Pei D.   +11 more
europepmc   +1 more source

Protein Modifications for Cellular Protein Delivery. [PDF]

Chem Rev
Arafiles JVV, Franke J, Dubatouka P, Franz L, Hackenberger CPR.   +4 more
europepmc   +1 more source