Results 211 to 220 of about 336,446 (348)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Membrane microdomains are crucial for <i>Mycobacterium marinum</i> EsxA-dependent membrane damage, escape to the cytosol, and infection. [PDF]

Sci Adv
Perret A, Bosmani C, Leuba F, Eblighatian K, Guého A, Raykov L, Hanna N, Soldati T.   +7 more
europepmc   +1 more source

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

, 2020
Nga Nguyen, Kuo Du, Jephte Y. Akakpo, David S. Umbaugh, Hartmut Jaeschke, Anup Ramachandran   +5 more
openalex   +2 more sources

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics. [PDF]

ACS Nano
Chahal GS, Helbig KJ, Parton RG, Monson EA.   +3 more
europepmc   +1 more source

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver [PDF]

, 1979
Suresh K. Joseph, Norah M. Bradford, J D McGivan   +2 more
openalex   +1 more source

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

Cell, 2011
F. Edlich, Soojay Banerjee, Motoshi Suzuki, Megan M. Cleland, D. Arnoult, Chunxin Wang, A. Neutzner, N. Tjandra, R. Youle   +8 more
semanticscholar   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

Prevalence of germline MSH3 polymorphisms in ulcerative colitis and early-onset colorectal cancer patients that potentiates inflammation-to-cancer transformation. [PDF]

Hum Mol Genet
Tseng-Rogenski SS, Venugopal A, Koi M, Carethers JM.   +3 more
europepmc   +1 more source

Release of Signal Peptide Fragments into the Cytosol Requires Cleavage in the Transmembrane Region by a Protease Activity That Is Specifically Blocked by a Novel Cysteine Protease Inhibitor [PDF]

, 2000
Andreas Weihofen, Marius K. Lemberg, Hidde L. Ploegh, Matthew Bogyo, Bruno Martoglio   +4 more
openalex   +1 more source