Results 221 to 230 of about 453,295 (313)

Modulating Subcellular Localization to Preserve the Stability and Functionality of Intracellular Nanobodies. [PDF]

Antibodies (Basel)
Sun W, Huang K, Cheng Y, Huang A, Kong Y, Lu J, Ying T, Wu Y.   +7 more
europepmc   +1 more source

Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol [PDF]

, 1985
Kurt Von Figura, Volkmar Gieselmann, Andrej Hasilík   +2 more
openalex   +1 more source

In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments

Advanced Science, EarlyView.
Here, an open microfluidic platform termed “µ‐Blood” is reported for real‐time, continuous monitoring of Babesia microti infection dynamics in vitro. µ‐Blood allows direct interrogation of whole blood with preserved integrity of the original whole blood microenvironment through an extended period (e.g., 72 h with mouse red blood cells) ex vivo. µ‐Blood
Chao Li, Emily G. Bache, Amy L. Apgar, Danielle M. Tufts, Tagbo H. R. Niepa   +4 more
wiley   +1 more source

Reprogramming chemically induced dimerization systems with genetically encoded nanobodies. [PDF]

Chem Sci
Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, Zhou Y.   +6 more
europepmc   +1 more source

Soluble phorbol ester binding sites and phospholipid‐ and calcium‐dependent protein kinase activity in cytosol of chick oviduct [PDF]

, 1983
Michael Gschwendt, Friedemann Horn, Walter Kittstein, Gerhard Fürstenberger, Friedrich Marks   +4 more
openalex   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis. [PDF]

Nat Commun
Tran VG, Tan SI, Xu H, Weilandt DR, Li X, Bhagwat SS, Zhu Z, Guest JS, Rabinowitz JD, Zhao H.   +9 more
europepmc   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

An overview of the interconnectedness of the PEXEL and non-PEXEL mediated protein export in <i>Plasmodium falciparum</i>. [PDF]

iScience
Das S.
europepmc   +1 more source

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source