Results 251 to 260 of about 453,295 (313)

Cilastatin Modulates DPEP1- and IQGAP1-Associated Neuro-Glio-Vascular Inflammation in Oxaliplatin-Induced Peripheral Neurotoxicity. [PDF]

Cells
Martín-Ramírez R, González-Nicolás MÁ, Álvarez-Tosco K, Machín F, Ávila J, Morales M, Lázaro A, Martín-Vasallo P.   +7 more
europepmc   +1 more source

Inhibition of 5β-Dihydrocortisone Reduction in Rat Liver Cytosol: A Rapid Spectrophotometric Screen for Nonsteroidal Anti-Inflammatory Drug Potency

, 1985
T.M. Penning
openalex   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Biomedical Applications of Nanozymes: An Enzymology Perspective

Angewandte Chemie, EarlyView.
With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov, Xiaohan Zhang, Ka‐Ying Wong, Jung Heon Lee, Juewen Liu   +4 more
wiley   +2 more sources

Quantitative cellular characterization of extracellular mitochondria uptake and delivery. [PDF]

Nat Commun
Al Amir Dache Z, Chevé M, Dancourt J, Lavieu G.   +3 more
europepmc   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, EarlyView.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

The global proteome of <i>Streptococcus pneumoniae</i> EF3030 under nutrient-defined <i>in vitro</i> conditions. [PDF]

Front Cell Infect Microbiol
De S, Busch LM, Burchhardt G, Gesell Salazar M, Schlüter R, Steil L, Völker U, Hammerschmidt S.   +7 more
europepmc   +1 more source

Cytosol-Membrane Interface of Human Erythrocytes

, 1983
J. Eisinger, Jorge Flores
openalex   +1 more source

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

Advanced Science, EarlyView.
Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen, Zhe Feng, Siyuan Wang, Jingjing Zhang   +3 more
wiley   +1 more source

Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine–Isonitrile Reaction

Angewandte Chemie, EarlyView.
Rhenium(I) tetrazylmethyl complexes serve as phosphorogenic bioorthogonal reagents, releasing luminescent and photocytotoxic rhenium(I) 3‐hydroxypyridine complexes and functional payloads upon reaction with 3‐isocyanopropyl derivatives. Their selective lysosomal accumulation in cancer cells and enhanced singlet oxygen photosensitization in acidic ...
Eunice Chiu‐Lam Mak, Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo   +2 more
wiley   +2 more sources