Results 21 to 30 of about 322,139 (355)
Microbial Cell, 2014 Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress,
Marizela Delic +6 more
doaj +1 more source
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
Journal of Cell Biology, 1997 Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the ...
K. Wolter +5 more
semanticscholar +1 more source
The Mitochondria-to-Cytosol H2O2 Gradient Is Caused by Peroxiredoxin-Dependent Cytosolic Scavenging [PDF]
Antioxidants, 2021 Fluorescent protein-based reporters used to measure intracellular H2O2 were developed to overcome the limitations of small permeable dyes. The two major families of genetically encoded redox reporters are the reduction-oxidation sensitive green fluorescent protein (roGFP)-based proteins fused to peroxiredoxins and HyPer and derivatives.
Laura de Cubas +4 more
openaire +5 more sources
eLife, 2017 The cytosol-facing membranes of cellular organelles contain proteins that enable signal transduction, regulation of morphology and trafficking, protein import and export, and other specialized processes.
Victoria Hung +7 more
semanticscholar +1 more source
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
BMC Biology, 2018 Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy mitochondrial network, is initiated by activation of the PINK1 kinase ...
Shiori Sekine, R. Youle
semanticscholar +1 more source
Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers
Theranostics, 2019 Protein delivery into cells is a potentially transformative tool for treating “undruggable” targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for
Yiwei Lee +6 more
semanticscholar +1 more source
Life, 2017 Background: The transformation of the supported lipid bilayer (SLB) membrane by extracted cytosol from living resources, has recently drawn much attention. It enables us to address the question of whether the purified phospholipid SLB membrane, including
Kei Takahashi, Taro Toyota
doaj +1 more source
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access
Cellular Microbiology, 2016 Mycobacterium tuberculosis, the infectious agent of human tuberculosis is a master player in circumventing the defense mechanisms of the host immune system. The host-pathogen interaction in the case of an infection with M. tuberculosis is highly complex, involving dedicated mycobacterial virulence factors as well as the action of the innate and adapted
Simeone, Roxane +3 more
openaire +4 more sources
Cytosolic Prion Protein in Neurons [PDF]
The Journal of Neuroscience, 2003 Localizing the cellular prion protein (PrPC) in the brain is necessary for understanding the pathogenesis of prion diseases. However, the precise ultrastructural localization of PrPC still remains enigmatic. We performed the first quantitative study of the ultrastructural localization of PrPC in the mouse hippocampus using high-resolution ...
Mironov, A. +9 more
openaire +4 more sources
On the Origin and Fate of Reactive Oxygen Species in Plant Cell Compartments
Antioxidants, 2019 Reactive oxygen species (ROS) have been recognized as important signaling compounds of major importance in a number of developmental and physiological processes in plants.
Martina Janků +2 more
doaj +1 more source