Results 31 to 40 of about 256,621 (293)
Characterization of the Cytosolic Tuberin-Hamartin Complex [PDF]
Journal of Biological Chemistry, 1999 Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by a broad phenotypic spectrum that includes seizures, mental retardation, renal dysfunction and dermatological abnormalities. Mutations to either the TSC1 or TSC2 gene are responsible for the disease.
Marjon van Slegtenhorst +5 more
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PLoS Pathogens, 2021 Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium colonizes epithelial cells lining the gastrointestinal tract. S.
TuShun R Powers +8 more
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Microbial Cell, 2014 Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress,
Marizela Delic +6 more
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, 2006 The crowded cytosol is a special environment where weak interactions can be important. Here many macromolecules are close to the limits of their solubility, a condition conducive to weak, but specific, entropy-driven molecular interactions. In addition to being under evolutionary constraint to preserve the functions of their own products, genes ...
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Life cycle of cytosolic prions [PDF]
Prion, 2013 Prions are self-templating protein aggregates that were originally identified as the causative agent of prion diseases in mammals, but have since been discovered in other kingdoms. Mammalian prions represent a unique class of infectious agents that are composed of misfolded prion protein.
Hofmann, Julia, Vorberg, Ina
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Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
eLife, 2017 Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules.
Margarida Moura +7 more
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Expression and localization of two β-carbonic anhydrases in Bienertia, a single-cell C4 plant
Frontiers in Plant ScienceCarbonic anhydrases (CAs) are ubiquitous enzymes that catalyze reversibly both the hydration and dehydration reactions of CO2 and HCO3-, respectively.
Tho Nguyen +8 more
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Cold Spring Harbor Perspectives in Biology, 2010 "Ca(2+) buffers," a class of cytosolic Ca(2+)-binding proteins, act as modulators of short-lived intracellular Ca(2+) signals; they affect both the temporal and spatial aspects of these transient increases in [Ca(2+)](i). Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin.
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CellsLysosomes are subcellular compartments characterised by an acidic pH, containing an ample variety of acid hydrolases involved in the recycling of biopolymers.
Ryan Conesa-Bakkali +2 more
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Cytosol intermediates in the transport of iron [PDF]
Blood, 1980 Abstract Three 59Fe-labeled nonheme components of the cytosol were identified when rabbit reticuloyctes were incubated with 59Fe-labeled plasma under conditions in which the iron supply was not limiting. Two of these components were identified as ferritin and transferrin.
Edward S. Cole +2 more
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