Results 51 to 60 of about 389,979 (247)

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

Nature Communications, 2016
Immune recognition of cytosolic DNA represents a central antiviral defence mechanism. Within the host, short single-stranded DNA (ssDNA) continuously arises during the repair of DNA damage induced by endogenous and environmental genotoxic stress. Here we
C. Wolf, A. Rapp, N. Berndt, W. Staroske, Max Schuster, Manuela Dobrick-Mattheuer, S. Kretschmer, N. König, T. Kurth, D. Wieczorek, K. Kast, M. C. Cardoso, C. Günther, M. Lee-Kirsch   +13 more
semanticscholar   +1 more source

Plastidäre Vorläuferproteine im Cytosol : Import vs. Degradation [PDF]

, 2019
In Arabidopsis thaliana ist der Großteil plastidärer Proteine im Zellkern kodiert und wird im Cytosol als Vorläuferproteine synthetisiert. Hier unterliegen Vorläuferproteine Modifikationen und Regulationen, die weitestgehend unbekannt sind.
Grimmer, Julia
core   +1 more source

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

eLife, 2017
Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules.
Margarida Moura, Mariana Osswald, Nelson Leça, João Barbosa, António J Pereira, Helder Maiato, Claudio E Sunkel, Carlos Conde   +7 more
doaj   +1 more source

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A., Roberts, David M, Roberts, Lynne M, Lord, J Michael, Cook, Jonathan P., Pietroni, Paola, Roberts, David M., Lord, Mike, Roberts, L. M. (Lynne M.), Spooner, Robert A, Vasisht, Nishi, Hartmann-Petersen, Rasmus, Cook, Jonathan P   +12 more
core   +1 more source

Diurnal changes of subcellular glutathione content in Arabidopsis thaliana

Biologia Plantarum, 2017
The aim of this study was to investigate diurnal changes of subcellular glutathione content in leaves of Arabidopsis thaliana by immunohistochemistry and quantitative transmission electron microscopy.
B. Zechmann
doaj   +1 more source

Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy

Cells
Lysosomes are subcellular compartments characterised by an acidic pH, containing an ample variety of acid hydrolases involved in the recycling of biopolymers.
Ryan Conesa-Bakkali, Macarena Morillo-Huesca, Jonathan Martínez-Fábregas   +2 more
doaj   +1 more source

Release of cathepsin-B in cytosol causes cell death in acute pancreatitis

Gastroenterology, 2016
BACKGROUND & AIMS Experimental studies in acute pancreatitis (AP) suggest strong association of acinar cell injury with cathepsin-B dependent intracellular activation of trypsin.
R. Talukdar, Archana Sareen, Hongyan Zhu, Zuobiao Yuan, A. Dixit, Hassam Cheema, J. George, Usman Barlass, R. Sah, Sushil Garg, Sulagna Banerjee, P. Garg, V. Dudeja, R. Dawra, A. Saluja   +14 more
semanticscholar   +1 more source

Expression and localization of two β-carbonic anhydrases in Bienertia, a single-cell C4 plant

Frontiers in Plant Science
Carbonic anhydrases (CAs) are ubiquitous enzymes that catalyze reversibly both the hydration and dehydration reactions of CO2 and HCO3-, respectively.
Tho Nguyen, Nakyoung Lee, Fabian J. Frömling, Toni L. Meister, Toni L. Meister, Toni L. Meister, Jung Sun Kim, Sascha Offermann, Inhwan Hwang   +8 more
doaj   +1 more source

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

Journal of Cell Biology, 1996
Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran GTP/GDP cycle is the 70-kD Ran-GTPase-activating protein RanGAP1.
M. Matunis, E. Coutavas, G. Blobel
semanticscholar   +1 more source

RxLxE GFP chimeras are exported into the RBC cytosol. [PDF]

, 2013
Pb070060, Pb136550 and Pb140070 were exported into the RBC cytosol. Full-length expression of Pb114540-GFP could not be obtained, however, two shorter versions (Pb114540F3 and Pb114540F2) were expressed and exported into the host cell cytosol.
Kathryn Matthews (407653), Tania F. de Koning-Ward (407655), Eric Hanssen (349226), Ming Kalanon (407654), Silvia Haase (266944)   +4 more
core   +1 more source