Results 61 to 70 of about 323,927 (286)

Bacteria arise at the border of mycoplasma-infected HeLa cells, containing cytoplasm with either malformed cytosol, mitochondria and endoplasmic reticulum or tightly adjoined smooth vacuoles

Revista do Instituto de Medicina Tropical de São Paulo, 2017
A study with transmission electron microscopy of mycoplasma-contaminated HeLa cells using five cell donors referred to as donors A, B, C, D and E, observations are herein presented.
Antonio Sesso, Edite Hatsumi Yamashiro-Kanashiro, Liã Bárbara Arruda, Joyce Kawakami, Maria de Lourdes Higuchi, Noemia Mie Orii, Noemi Nosomi Taniwaki, Flávia Mendes da Cunha Carvalho, Mariane Pereira Brito, Maiara Gottardi, Sylvia Mendes Carneiro, Rumio Taga   +11 more
doaj   +1 more source

Predicting liver cytosol stability of small molecules

Journal of Cheminformatics, 2020
Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of ...
Pranav Shah, Vishal B. Siramshetty, Alexey V. Zakharov, Noel T. Southall, Xin Xu, Dac-Trung Nguyen   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Enzymatic and non-enzymatic link components of antioxidant defence in subcellular fractions of rat liver under the influence of diethyl phthalate

Біологічні студії
Background. The antioxidant system is one of the protective cell systems. Changes in its functioning, after the introduction of xenobiotics into the body, will determine the further course of the intensity of free radical processes.
Oksana Ketsa, Anastasia Shvets, Mykhailo Marchenko   +2 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Properties of triiodothyronine-binding proteins in liver cytosol of rat

, 1983
The electrophoretic mobility and the sedimentation coefficient were determined in partially purified preparations of both rat liver cytosol and serum triiodothyronine (T3)-binding proteins.
S. Bédard, J. -G. Lehoux, D. Bellabarba
core   +1 more source

SGTA regulates the cytosolic quality control of hydrophobic substrates [PDF]

, 2014
Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides.
Payapilly, Aishwarya, Leznicki, Pawel, High, Stephen; id_orcid, High, Stephen, Wunderley, Lydia   +4 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Protein aggregation profile of the bacterial cytosol. [PDF]

PLoS ONE, 2010
BACKGROUND: Protein misfolding is usually deleterious for the cell, either as a consequence of the loss of protein function or the buildup of insoluble and toxic aggregates.
Natalia S de Groot, Salvador Ventura
doaj   +1 more source

Regulation of the 26S Proteasome: From Homeostasis to Stress and Disease

Cells
The ubiquitin–proteasome system (UPS) has traditionally been described as a tightly regulated degradative network driven mainly by the specificity of its ubiquitin-conjugating enzymatic components.
Victoria Cohen-Kaplan, Aaron Ciechanover, Yelena Kravtsova-Ivantsiv   +2 more
doaj   +1 more source