Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
Molecules and Cells, 2014 Summary Eukaryotic cells compartmentalize biochemical processes in different organelles, often relying on metabolic cycles to shuttle reducing equivalents across intracellular membranes.
C. Lewis +9 more
semanticscholar +1 more source
Cold Spring Harbor Perspectives in Biology, 2010 "Ca(2+) buffers," a class of cytosolic Ca(2+)-binding proteins, act as modulators of short-lived intracellular Ca(2+) signals; they affect both the temporal and spatial aspects of these transient increases in [Ca(2+)](i). Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin.
openaire +3 more sources
How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]
, 2012 A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core
Acidification of the cytosol inhibits endocytosis from coated pits. [PDF]
, 1987 Acidification of the cytosol of a number of different cell lines strongly reduced the endocytic uptake of transferrin and epidermal growth factor. The number of transferrin binding sites at the cell surface was increased in acidified cells.
K Sandvig +7 more
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Delivering proteins for export from the cytosol. [PDF]
, 2009 Correct protein function depends on delivery to the appropriate cellular or subcellular compartment. Following the initiation of protein synthesis in the cytosol, many bacterial and eukaryotic proteins must be integrated into or transported across a ...
Sinning, I +4 more
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Redox characteristics of the eukaryotic cytosol [PDF]
, 2007 The eukaryotic cytoplasm has long been regarded as a cellular compartment in which the reduced state of protein cysteines is largely favored. Under normal conditions, the cytosolic low-molecular weight redox buffer, comprising primarily of glutathione ...
López-Mirabal, H Reynaldo +3 more
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Aequorin-based measurements of intracellular Ca2+-signatures in plant cells
Biological Procedures Online, 2002 Due to the involvement of calcium as a main second messenger in the plant signaling pathway, increasing interest has been focused on the calcium signatures supposed to be involved in the patterning of the specific response associated to a given stimulus.
Mithöfer Axel, Mazars Christian
doaj +1 more source
Pitfalls of Mitochondrial Redox Signaling Research
Antioxidants, 2023 Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto-isocaproate (KIC) β-like-oxidation stimulating insulin secretion in pancreatic β ...
Petr Ježek
doaj +1 more source
The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]
, 2006 Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T +20 more
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Protein aggregation profile of the bacterial cytosol. [PDF]
PLoS ONE, 2010 BACKGROUND: Protein misfolding is usually deleterious for the cell, either as a consequence of the loss of protein function or the buildup of insoluble and toxic aggregates.
Natalia S de Groot, Salvador Ventura
doaj +1 more source