Results 51 to 60 of about 453,295 (313)

Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism [PDF]

, 2008
The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion.
Asher, Bakker, Barlowe, Barlowe, Benatti, Blanchard, Brandizzi, Brauer, Braun, Carter, Contento, d'Enfert, d'Enfert, de Virgilio, Di Cola, Di Cola, Donoso, Ellgaard, Endo, Feiler, Fenteany, Ferrini, Frigerio, Frigerio, Frigerio, Frigerio, Frigerio, Gillespie, Glas, Hellens, Hong, Jarosch, Jolliffe, Jolliffe, Katiyar, Kisselev, Kong, Lord, Lord, Loureiro, Ma, Maliga, Marshall, Meng, Meusser, Muller, Nebenfuhr, Nuttall, Nuttall, Parodi, Pedrazzini, Phillipson, Pimpl, Rancour, Reichel, Roberts, Romisch, Saint-Jore-Dupas, Schmitz, Schmitz, Sheng, Smith, Speranza, Tabe, Taiz, Tamura, Tolchinsky, Tormakangas, Tsai, Vitale, Wales, Ye, Ye, Yuk   +73 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

From vesicle to cytosol

eLife, 2018
Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Michael J Rogers, Marcia A Munoz
doaj   +1 more source

Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol. [PDF]

PLoS Genetics, 2018
Zinc is an essential trace element that is required for the function of a large number of proteins. As these zinc-binding proteins are found within the cytosol and organelles, all eukaryotes require mechanisms to ensure that zinc is delivered to ...
Sangyong Choi, Ya-Mei Hu, Mark E Corkins, Amy E Palmer, Amanda J Bird   +4 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Aequorin-based measurements of intracellular Ca²⁺-signatures in plant cells

Biological Procedures Online, 2002
Due to the involvement of calcium as a main second messenger in the plant signaling pathway, increasing interest has been focused on the calcium signatures supposed to be involved in the patterning of the specific response associated to a given stimulus.
Mithöfer Axel, Mazars Christian
doaj   +1 more source

Predicting liver cytosol stability of small molecules

Journal of Cheminformatics, 2020
Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of ...
Pranav Shah, Vishal B. Siramshetty, Alexey V. Zakharov, Noel T. Southall, Xin Xu, Dac-Trung Nguyen   +5 more
doaj   +1 more source

Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons

Cell Reports, 2023
Summary: The metabolic prohormone pro-opiomelanocortin (POMC) is generally translocated into the endoplasmic reticulum (ER) for entry into the secretory pathway.
Sang-Hyeon Mun, Chang-Seok Lee, Hyun Jin Kim, Jiye Kim, Haena Lee, Jihye Yang, Sin-Hyeog Im, Joung-Hun Kim, Je Kyung Seong, Cheol-Sang Hwang   +9 more
doaj   +1 more source

A nonmitochondrial hydrogen production in Naegleria gruberi [PDF]

, 2014
Naegleria gruberi is a free-living heterotrophic aerobic amoeba well known for its ability to transform from an amoeba to a flagellate form. The genome of N.
Anastasios D. Tsaousis, Bui, Cable, Ellis, Embley, Embley, Embley, Eva Nývltová, Fritz-Laylin, Fritz-Laylin, Fromm, Fulton, Helianti, Hug, Ivan Hrdý, Jan Tachezy, Kamp, Koonin, Lithgow, Lloyd, Majewski, Martin, Mentel, Meyer, Muller, Netz, Nicolet, Niedenthal, Nixon, Nyvltova, Opperdoes, Peters, Putz, Rasoloson, Robert Šuták, Sambrook, Stechmann, Sutak, Tsaousis, Vignais   +39 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source