Results 71 to 80 of about 322,139 (355)

Bacteria arise at the border of mycoplasma-infected HeLa cells, containing cytoplasm with either malformed cytosol, mitochondria and endoplasmic reticulum or tightly adjoined smooth vacuoles

Revista do Instituto de Medicina Tropical de São Paulo, 2017
A study with transmission electron microscopy of mycoplasma-contaminated HeLa cells using five cell donors referred to as donors A, B, C, D and E, observations are herein presented.
Antonio Sesso, Edite Hatsumi Yamashiro-Kanashiro, Liã Bárbara Arruda, Joyce Kawakami, Maria de Lourdes Higuchi, Noemia Mie Orii, Noemi Nosomi Taniwaki, Flávia Mendes da Cunha Carvalho, Mariane Pereira Brito, Maiara Gottardi, Sylvia Mendes Carneiro, Rumio Taga   +11 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Endoplasmic reticulum calcium regulates the retrotranslocation of Trypanosoma cruzi calreticulin to the cytosol. [PDF]

PLoS ONE, 2010
For most secretory pathway proteins, crossing the endoplasmic reticulum (ER) membrane is an irreversible process. However, in some cases this flow can be reversed.
Carlos A Labriola, Ianina L Conte, Máximo López Medus, Armando J Parodi, Julio J Caramelo   +4 more
doaj   +1 more source

Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5

Biophysical Reports, 2022
Cellular functions rely on proper actions of organelles such as peroxisomes. These organelles rely on the import of proteins from the cytosol. The peroxisomal import receptor PEX5 takes up target proteins in the cytosol and transports them to the ...
S. Galiani, K. Reglinski, P. Carravilla, A. Barbotin, I. Urbančič, J. Ott, J. Sehr, E. Sezgin, F. Schneider, D. Waithe, P. Hublitz, W. Schliebs, R. Erdmann, C. Eggeling   +13 more
doaj   +1 more source

Cytosolic Chaperonins: a Question of Promiscuity [PDF]

Molecular Cell, 2006
Chaperonins in the eukaryotic cytosol are more mysterious than their bacterial counterparts, with a heterogeneity of protein binding surfaces. In a recent issue of Molecular Cell, showed that binding specificity in the TRiC chaperonin is less than absolute and resolved the location of substrate binding surfaces in this chaperonin.
openaire   +4 more sources

Cytosolic surveillance and antiviral immunity [PDF]

Current Opinion in Virology, 2011
Innate immune surveillance mechanisms lie at the heart of the antiviral response. A growing number of germ-line encoded pattern recognition receptors have been identified which protect the host from infection by sensing the presence of viral molecules and inducing antiviral defenses.
Vijay A. K. Rathinam, Katherine A. Fitzgerald   +1 more
openaire   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Redox characteristics of the eukaryotic cytosol

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008
The eukaryotic cytoplasm has long been regarded as a cellular compartment in which the reduced state of protein cysteines is largely favored. Under normal conditions, the cytosolic low-molecular weight redox buffer, comprising primarily of glutathione, is highly reducing and reactive oxygen species (ROS) and glutathionylated proteins are maintained at ...
López-Mirabal, H Reynaldo, Winther, Jakob R   +1 more
openaire   +4 more sources

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocation. [PDF]

PLoS ONE, 2013
Following retrograde trafficking to the endoplasmic reticulum (ER), cholera toxin A1 (CTA1) subunit hijacks ER-associated degradation (ERAD) machinery and retro-translocates into the cytosol to induce toxicity.
Paul Moore, Kaiyu He, Billy Tsai
doaj   +1 more source