Results 81 to 90 of about 256,621 (293)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Ultra‐Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling

Advanced Materials, EarlyView.
3D bioprinting merges tissue engineering and additive manufacturing to create biological structures. A bioink is developed by modifying hyaluronic acid, a natural extracellular matrix polymer, with cysteine. Potassium iodide is later added to tune gelation kinetics, enabling fine printing with a 32G needle.
Shima Tavakoli, Aybike Kocatürkmen, Oommen P. Oommen, Oommen P. Varghese   +3 more
wiley   +1 more source

A Conditionally Activated Cytosol-Penetrating Antibody for TME-Dependent Intracellular Cargo Delivery

Antibodies
Currently, therapeutic and diagnostic applications of antibodies are primarily limited to cell surface-exposed and extracellular proteins. However, research has been conducted on cell-penetrating peptides (CPP), as well as cytosol-penetrating antibodies,
Carolin Sophie Dombrowsky, Dominic Happel, Jan Habermann, Sarah Hofmann, Sasi Otmi, Benny Cohen, Harald Kolmar   +6 more
doaj   +1 more source

Characterization of cytosol phosphopeptides [PDF]

FEBS Letters, 1973
PINNA, LORENZO, DONELLA, ARIANNA, MORET, VITTORIO   +2 more
openaire   +3 more sources

Flippase‐Mediated Hybrid Vesicle Division

Advanced Materials, EarlyView.
The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′‐triphosphate consumption and flipping of 2‐dioleoyl‐sn‐glycero‐3‐phospho‐l‐serine lipids from the inner to the outer leaflet.
Paula De Dios Andres, Amalie Benfeldt Purup, Grégory Beaune, Jaakko V. I. Timonen, Joseph A. Lyons, Brigitte Städler   +5 more
wiley   +1 more source

Biocompatibility and Long‐Term Stability of DNA‐Based Organic Mixed Conductors for Bioelectronics

Advanced Materials Interfaces, EarlyView.
The biocompatibility and long‐term stability of DNA‐based mixed ionic‐electronic conductors are investigated. In vitro cytotoxicity and cell viability are assessed using flow cytometry assay on primary mouse fibroblasts cultures. The biocomposites are integrated into organic electrochemical transistors (OECTs) to determine the stability of their ...
Sarka Hradilova, Katharina Matura, Munise Cobet, Ariana Opletalova, Yolanda Salinas, Niyazi Serdar Sariciftci, Serpil Tekoglu, Katerina Polakova   +7 more
wiley   +1 more source

A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol.

PLoS Pathogens, 2011
Non-enveloped viruses penetrate host membranes to infect cells. A cell-based assay was used to probe the endoplasmic reticulum (ER)-to-cytosol membrane transport of the non-enveloped SV40.
Takamasa Inoue, Billy Tsai
doaj   +1 more source

Malate dehydrogenase of the cytosol. A kinetic investigation of the reaction mechanism and a comparison with lactate dehydrogenase [PDF]

, 1978
A. Lodola, Joseph D. Shore, David M. Parker, J. John Holbrook   +3 more
openalex   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source