Results 51 to 60 of about 29,630 (208)

Immunocytochemical Phenotyping of Disseminated Tumor Cells in Bone Marrow by uPA Receptor and CK18: Investigation of Sensitivity and Specificity of an Immunogold/Alkaline Phosphatase Double Staining Protocol [PDF]

, 1997
Phenotyping of cytokeratin (CK) 18-positive cells in bone marrow is gaining increasing importance for future prognostic screening of carcinoma patients. Urokinase-type plasminogen activator receptor (uPA-R) is one example of a potential aggressive marker
Allgayer, Heike, Babic, Rudolf, Heiss, Markus Maria, Jauch, Karl-Walter, Riesenberg, Rainer, Schildberg, Friedrich Wilhelm   +5 more
core   +1 more source

Preanalytic specimen triage: Smears, cell blocks, cytospin preparations, transport media, and cytobanking [PDF]

Cancer Cytopathology, 2017
With increasing requests for the evaluation of prognostic and predictive molecular biomarkers, great attention must be paid to the preanalytical issues regarding sample quality and DNA/RNA yield from all different types of cytological preparations. The objectives of this review were: 1) to provide an update regarding the importance of specimen triage ...
Gilda, da Cunha Santos, Mauro A, Saieg
openaire   +2 more sources

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source

Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps

Allergy, Asthma & Clinical Immunology, 2018
Background Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation.
Yang Peng, Wei-jie Guan, Kai Sen Tan, Zhenchao Zhu, Zhuo Chen, Haiyu Hong, Zhaoni Wang, Tengfei Tian, Xiaoxue Zi, Yew Kwang Ong, Mark Thong, Li Shi, Qintai Yang, Qianhui Qiu, De-Yun Wang   +14 more
doaj   +1 more source

Rapid weight gain: An unusual presentation of leukemia

Indian Journal of Medical and Paediatric Oncology, 2020
Neurological manifestations of leukemia can be due to direct effects of the malignancy or due to the indirect effects of infection or therapy. An 11-year-old boy presented with recent-onset weight gain with papilledema and a history of tuberculosis ...
Ranjini Srinivasan, Sarita Thomas
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Regulation of neutrophil senescence by microRNAs [PDF]

, 2011
Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants,
A Bonauer, A Lee, AD Kennedy, AS Cowburn, AW Ford-Hutchinson, C Haslett, C Martin, CH Wang, CL Andersen, DP Bartel, E Berezikov, E Tsitsiou, EP Cronkite, F Bazzoni, F Colotta, F Fazi, Frank R. DeLeo, GM Bokoch, H Su, H Xia, I Sabroe, I Sabroe, J Davidson-Moncada, J Savill, J Yu, James W. Catto, JB Johnnidis, JJ Lum, JL Mott, Jon R. Ward, JR Ward, LR Prince, M Merkerova, M Scherr, Marta Milo, MK Whyte, MK Whyte, Moira K. B. Whyte, OD Weiner, P Scapini, PA Davoren, Paul R. Heath, PT Nelson, R Chhabra, R Yi, RE Stringer, RW Watson, S Huang, S Radom-Aizik, S Slezak, SA Renshaw, SD Kobayashi, SD Kobayashi, Stephen A. Renshaw, W Filipowicz, W Huang da, WC Liles, WP Tsang, Y Lee, Y Wang, YZ Pan   +60 more
core   +5 more sources

Isolated CNS Blast Crises in Chronic Myeloid Leukaemia Presenting as Hypertrophic Pachymeningitis and Bilateral Optic Neuritis: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Extramedullary blast crises of Chronic Myeloid Leukaemia (CML) involving CNS is rare and usually accompanies systemic relapse. Isolated CNS blast relapse is an extremely uncommon event.
Ankur Jain, Naresh Gupta
doaj   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound‐Guided Fine‐Needle Aspiration—Cyto‐Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López, Mónica Elizabeth Bauza, Judith Pérez‐Rojas, Cecilia López‐Valdivia, Carlos Zac Romero, Óscar Castells‐Perona, Cristina Ballester‐Ibáñez, Eva Montalvá‐Orón, Rafael López‐Andújar, Lidia Argüello‐Viudez, Mireya Prieto Rodríguez   +10 more
wiley   +1 more source