Results 51 to 60 of about 30,637 (206)

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness [PDF]

, 2015
BackgroundPractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4.
Dhariwal, J, Francombe, G, Gilbert, J, Hansel, TT, Jones, RE, Kitson, J, Kon, OM, Murdoch, R, Nicholson, G, Openshaw, PJ, Tan, AJ, Tunstall, T, Walton, RP   +12 more
core   +6 more sources

Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human [PDF]

, 2015
"Copyright: © 2015 Madhukaran, Kishore, Jamil, Teo, Choolani and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Choolani, M, Jamil, K, Kishore, U, Lu, J, Madhukaran, SP, Teo, BHD   +5 more
core   +2 more sources

Preanalytic specimen triage: Smears, cell blocks, cytospin preparations, transport media, and cytobanking [PDF]

Cancer Cytopathology, 2017
With increasing requests for the evaluation of prognostic and predictive molecular biomarkers, great attention must be paid to the preanalytical issues regarding sample quality and DNA/RNA yield from all different types of cytological preparations. The objectives of this review were: 1) to provide an update regarding the importance of specimen triage ...
Gilda, da Cunha Santos, Mauro A, Saieg
openaire   +2 more sources

Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps

Allergy, Asthma & Clinical Immunology, 2018
Background Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation.
Yang Peng, Wei-jie Guan, Kai Sen Tan, Zhenchao Zhu, Zhuo Chen, Haiyu Hong, Zhaoni Wang, Tengfei Tian, Xiaoxue Zi, Yew Kwang Ong, Mark Thong, Li Shi, Qintai Yang, Qianhui Qiu, De-Yun Wang   +14 more
doaj   +1 more source

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source

Rapid weight gain: An unusual presentation of leukemia

Indian Journal of Medical and Paediatric Oncology, 2020
Neurological manifestations of leukemia can be due to direct effects of the malignancy or due to the indirect effects of infection or therapy. An 11-year-old boy presented with recent-onset weight gain with papilledema and a history of tuberculosis ...
Ranjini Srinivasan, Sarita Thomas
doaj   +1 more source

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +2 more sources

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, EarlyView.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction [PDF]

, 2010
Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance.
Adenuga, Adenuga, Barnes, David Adenuga, Garbin, Goven, Harju, Hew, Hongwei Yao, Irfan Rahman, Isaac K. Sundar, Ito, Ito, Itoh, Jae-Woong Hwang, Jaiswal, Keatings, Kramer, Liu, Malhotra, Marwick, Rahman, Rangasamy, Samuel Caito, Sangwoon Chung, Southam, Sun, Tomaki, Trivedi, Yang, Yang, Yao, Yao, Zimmermann   +33 more
core   +1 more source