Results 101 to 110 of about 862,062 (313)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Biological Activities of Extracts from Sumac (Rhus spp.): A Review [PDF]

, 2007
Sumac is the common name for a genus (Rhus) that contains over 250 individual species of flowering plants in the family Anacardiaceae. These plants are found in temperate and tropical regions worldwide, often grow in areas of marginal agricultural ...
Giuseppe Mazza, Sierra Rayne
core   +2 more sources

Determination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentials

Heliyon
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first ...
Polat İpek, Mehmet Nuri Atalar, Ayşe Baran, Mehmet Fırat Baran, Mohammad Mehdi Ommati, Musa Karadag, Murat Zor, Aziz Eftekhari, Mehmet Hakkı Alma, Khaled Zoroufchi Benis, Fidan Nuriyeva, Rovshan Khalilov   +11 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub, Brander, Christian, Harlow, Jason D, Kalams, Spyros A, Sarkis, Phuong Thi Nguyen, Walker, Bruce D, Yang, Otto O   +6 more
core  

Unveiling interactions between DNA and cytotoxic 2-arylpiperidinyl-1,4-naphthoquinone derivatives: A combined electrochemical and computational study [PDF]

, 2018
Indexación: Scopus.Three 2-arylpiperidinyl-1,4-naphthoquinone derivatives were synthesized and evaluated in vitro to determine their cytotoxicity on cancer and normal cell lines.
Canales, C., Espinosa-Bustos, C., Jaque, P., Ramírez, G., Salas, C.O.   +4 more
core   +1 more source

Structure-activity studies with cytotoxic anthrapyrazoles

Oncology Reports, 2006
Anthrapyrazoles have been investigated as cancer chemotherapeutic agents. The mechanism of action of these compounds is thought to involve inhibition of DNA topoisomerase II. A structure-activity study was carried out to determine the in vitro cytotoxic activity of nine novel anthrapyrazoles against human breast carcinoma, head and neck squamous cell ...
Asher, Begleiter, Denny, Lin, Kimberly K, Larson, Jennifer, Lang, Xing, Wu, Teresa, Cabral, Hallie, Taylor, Lynn J, Guziec, Paul D, Kerr, Brian B, Hasinoff, Frank S, Guziec   +10 more
openaire   +3 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Antioxidant and Cytotoxic Activity of Water Ethanol Extracts from the Mycelium of Inonotus rheades (Pers.) Bondartsev & Singer [PDF]

Journal of Stress Physiology & Biochemistry, 2016
The important problem of current research is the search for bioactive natural compounds. We have previously demonstrated high in vitro antiradical activity of water ethanol extracts (WEE) from the mycelium species of the genus Inonotus rheades.
Borovskaya M.K., Gornostay T.G., Borovskii G.B.   +2 more
doaj  

Potential Cytotoxic Activity of Psephellus pyrrhoblepharus Extracts

Proceedings, 2017
Many species of Psephellus and Centaurea genuses have pharmacological activities including antiinflamatory, antipyretic, cytotoxic etc. Psephellus pyrrhoblepharus (Boiss.) Wagenitz (Centaurea pyrrhoblephara), an endemic plant, was collected from Elazığ ...
Pelin Taştan, Güliz Armagan, Taner Dağcı, Bijen Kıvçak   +3 more
doaj   +1 more source