Results 61 to 70 of about 842,255 (343)

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source

Activity Of Cytotoxic Lymphocytes In Patients With Preeclampsia

Interdisciplinary Approaches to Medicine, 2020
With preeclampsia, the average levels of biochemical parameters in mild and severe form did not differ significantly from those in the group with uncomplicated preeclampsia of pregnancy. There is a tendency to a decrease in total protein and an increase in bilirubin, creatinine, urea, and blood trans-ferases as it becomes heavier.
N V Kravtsova, A M Kurmanova, B K Amanzholova   +2 more
openaire   +4 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

(5Z,9Z)-14-[(3,28-Dioxoolean-12-en-28-yl)oxy]tetradeca-5,9-dienoic Acid with Cytotoxic Activity

Molbank
For the first time, a synthetic analogue of natural (5Z,9Z)-dienoic acid has been synthesized in the form of a hybrid molecule containing a fragment of oleanolic acid and (5Z,9Z)-tetradeca-5.9-dienedicarboxylic acid, synthesized using a new reaction of ...
Regina A. Tuktarova, Lilya U. Dzhemileva, Usein M. Dzhemilev   +2 more
doaj   +1 more source

ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF ALKALOIDS PRODUCED BY ENDOPHYTIC FUNGI

Proceedings of the Mongolian Academy of Sciences, 2018
In this study, 55 endophytic fungal strains isolated from alkaloid containing plants in Mongolia were screened for their production of alkaloids. TLC analysis of ethanolic crude extracts revealed the presence of alkaloids in 5 endophytic fungal strains ...
Amarbayasgalan M, Nomin M, Enkh-Amgalan J   +2 more
doaj   +1 more source

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]

, 2017
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C, BERNARDINI, Giovanni, CARDINALI, CLAUDIO, MORELLI, MARIA BEATRICE, Nabissi, M, SANTONI, Angela, Santoni, G., Santoni, M   +7 more
core   +1 more source

Inherited defects in lymphocyte cytotoxic activity

Immunological Reviews, 2010
Summary:  The granule‐dependent cytotoxic activity of lymphocytes plays a critical role in the defense against virally infected cells and tumor cells. The importance of this cytotoxic pathway in immune regulation is evidenced by the severe and often fatal condition, known as hemophagocytic lymphohistiocytic syndrome (HLH) that occurs in mice and humans
Geneviève de Saint Basile, Geneviève de Saint Basile, Geneviève de Saint Basile, Marjorie Côte, Marjorie Côte, Agathe Burgess, Agathe Burgess, Mickaël M. Ménager, Mickaël M. Ménager, Nadine Nehme, Nadine Nehme, Alain Fischer, Alain Fischer, Alain Fischer, Jana Pachlopnik Schmid, Jana Pachlopnik Schmid, Gaël Ménasché, Gaël Ménasché   +17 more
openaire   +3 more sources

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source

Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma [PDF]

, 2016
Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to a paucity of T cells within the tumor microenvironment (TME).
Alvarez, Hector A., Bailey, Peter, Biankin, Andrew V., Chang, David K., Chattopadhyay, Chandrani, Ekmekcioglu, Suhendan, Forget, Marie-Andrée, Grimm, Elizabeth A., Haymaker, Cara, Hwu, Patrick, Kim, Sun-Hee, Maitra, Anirban, Roszik, Jason, San Lucas, Francis A.   +13 more
core   +1 more source

Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins.

Biological and Pharmaceutical Bulletin, 2001
We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as ...
Yoshihiro Mimaki, Minpei Kuroda, Yutaka Sashida, Akihito Yokosuka   +3 more
openaire   +4 more sources