Results 91 to 100 of about 745,289 (215)
ADC Review / Journal of Antibody-drug Conjugates, 2020 Antibody-drug Conjugates or ADCs combine the selectivity of antibodies with the efficacy of small molecule drugs, allowing for more precise, targeted, therapeutic applications. Combining the advantages of antibodies in binding a specific target with the capabilities of a therapeutic payload, the majority of ADCs in preclinical and clinical development
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International Journal of Women's Health, 2023 Blair McNamara, Yifan Chang, Ashley Goreshnik, Alessandro D Santin Department of Obstetrics, Gynecology, and Reproductive Sciences Yale University School of Medicine, New Haven, CT, 06520, USACorrespondence: Alessandro D Santin, Obstetrics and Gynecology,
McNamara B +3 more
doaj
Photoswitchable Particles for On‐Demand Degradation and Triggered Release [PDF]
, 2013 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100171/1/smll_201201921_sm_suppl.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/100171/2/3051_ftp ...
Eyster, Thomas W. +7 more
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Datopotamab deruxtecan induces hallmarks of immunogenic cell death
Cell StressAntibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting tumor ...
Sabrina Forveille +4 more
doaj +1 more source
Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class.
Angewandte Chemie, 2018 The number of cytotoxic payload classes successfully employed in antibody-drug conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel mode of action will increase therapeutic options and potentially increase the ...
H. Lerchen +11 more
semanticscholar +1 more source
Inhalable fucoidan microparticles combining two antitubercular drugs with potential application in pulmonary tuberculosis therapy [PDF]
, 2018 The pulmonary delivery of antitubercular drugs is a promising approach to treat lung tuberculosis. This strategy not only allows targeting the infected organ instantly, it can also reduce the systemic adverse effects of the antibiotics. In light of that,
Ana Grenha +7 more
core +2 more sources
Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications
Pharmaceuticals, 2018 Chemotherapy is one of the major therapeutic options for cancer treatment. Chemotherapy is often associated with a low therapeutic window due to its poor specificity towards tumor cells/tissues.
Nirnoy Dan +6 more
doaj +1 more source
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy [PDF]
, 2015 Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor.
Fernández-Medarde, Alberto +1 more
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Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and [PDF]
, 2018 Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks.
Anderson, Daniel Griffith +11 more
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Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates
Molecular Cancer Therapeutics, 2018 Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Herein, we
C. Neumann +18 more
semanticscholar +1 more source