Results 111 to 120 of about 745,289 (215)

Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads

Xenobiotica
Stable isotope labelling by amino acids in cell culture (SILAC) is an established technique used in quantitative mass spectrometry (MS)-based proteomics. SILAC is also used to generate stable isotope labelled (SIL) antibodies for internal standards (IS) used in LC-MS/MS bioassays to improve quantitative robustness.Total antibody (TAb) is measured to ...
Vineet, Kumar, Alice, Chin, Abbie, Wong, Kristen A, Cardinal, Erica, McKinney, Shawna M, Hengel, Hao, Sun, Anthony J, Lee   +7 more
openaire   +2 more sources

Resistance to antibody–drug conjugates: A review

Acta Pharmaceutica Sinica B
Antibody–drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide.
Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K.W. To, Liwu Fu   +8 more
doaj   +1 more source

Current landscape of sequencing ADCs in metastatic breast cancer

Therapeutic Advances in Medical Oncology
Antibody-drug conjugates (ADCs) have revolutionized the care of advanced breast cancer. ADCs pair an antibody targeted against a tumor-associated antigen with a cytotoxic payload, aiming to deliver therapy more effectively and with fewer off-target ...
Shannon McLaughlin, Lis V. Ravani, Beverly Moy, Arielle J. Medford, Steven J. Isakoff, Ting Liu, Leif W. Ellisen, Laura M. Spring, Seth A. Wander, Rachel O. Abelman   +9 more
doaj   +1 more source

The CD123 antibody–drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia

HemaSphere
Antibody–drug conjugates (ADCs) combining monoclonal antibodies with cytotoxic payloads are a rapidly emerging class of immune‐based therapeutics with the potential to improve the treatment of cancer, including children with relapse/refractory acute ...
Ben Watts, Christopher M. Smith, Kathryn Evans, Andrew J. Gifford, Sara M. A. Mohamed, Stephen W. Erickson, Eric J. Earley, Steven Neuhauser, Timothy M. Stearns, Vivek M. Philip, Jeffrey H. Chuang, Patrick A. Zweidler‐McKay, Sribalaji Lakshmikanthan, Emily L. Jocoy, Carol J. Bult, Beverly A. Teicher, Malcolm A. Smith, Richard B. Lock   +17 more
doaj   +1 more source

Antibody–Drug Conjugates in Breast Cancer: Navigating Innovations, Overcoming Resistance, and Shaping Future Therapies

Biomedicines
Antibody–drug conjugates (ADCs) have revolutionized breast cancer (BC) therapy by combining targeted antibody specificity with potent cytotoxic payloads, thereby enhancing efficacy while minimizing systemic toxicity.
Hussein Sabit, Salma Abbas, Moataz T. El-Safoury, Engy M. Madkour, Sahar Mahmoud, Shaimaa Abdel-Ghany, Yasser Albrahim, Ibtesam S. Al-Dhuayan, Sanaa Rashwan, Ahmed El-Hashash, Borros Arneth   +10 more
doaj   +1 more source

Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies

Pharmaceuticals
Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in
Vitor Martins de Almeida, Milena Botelho Pereira Soares, Osvaldo Andrade Santos-Filho   +2 more
doaj   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ahuva Nissim, Ciara M. Finucane, Costantino Pitzalis, Danielle DiCara, Michele Bombardieri, Rita Jones, Sarah E. Wythe, Stephen J. Mather, Taher E. I. Taher, Y. K. Stella Man, Yuti Chernajovsky   +10 more
core   +1 more source

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning

Scientific Reports
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME).
Yutong Li, Ling Zuo, Xingyu Song, Yuyang Huang, Ke Zou, Xuan Dong, Hongwei Liu   +6 more
doaj   +1 more source

Novel "click"-ready pH-triggered phosphoramidate linker for controlled-release of cytotoxic payloads

, 2020
Clifford Berkman, Damilola Olabode, Feyisola Olatunji, Jacob Herman, Brittany Kesic   +4 more
openaire   +2 more sources

The 1984 NASA/ASEE summer faculty fellowship program [PDF]

An overview is given of the program management and activities. Participants and research advisors are listed. Abstracts give describe and present results of research assignments performed by 31 fellows either at the Johnson Space Center, at the White ...
Crow, B., Duke, M. B., Mcinnis, B. C.
core   +1 more source