Results 41 to 50 of about 745,289 (215)

Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells

Oncology Report, 2022
Targeted anticancer therapeutics offer the advantage of reducing cytotoxic side effects to normal cells by directing the cytotoxic payload selectively to cancer cells.
Tianqi Xu, Yongsheng Liu, A. Schulga, E. Konovalova, S. Deyev, V. Tolmachev, A. Vorobyeva   +6 more
semanticscholar   +1 more source

Biodegradable ion-exchange microspheres based on modified polylysines [PDF]

, 1995
Poly-L-lysine was synthesized via a triethylamine initiated ring-opening polymerization of Z-L-lysine-N'~-carboxyanhydride,\ud followed by deprotection of the E-amino group. Subsequently the polylysine was sulfamated using a pyridinium-sulfate complex to
Cremers, H.F.M., Feijen, J., Lens, J.P., Seymour, L.   +3 more
core   +4 more sources

Linker Architectures as Steric Auxiliaries for Altering Enzyme-Mediated Payload Release from Bioconjugates.

Bioconjugate chemistry, 2021
Protease-activated prodrugs leverage the increased activity of proteases in the tumor microenvironment and the tight regulation in healthy tissues to provide selective activation of cytotoxins in the tumor while minimizing toxicity to normal tissues. One
M. Giese, P. D. Davis, R. Woodman, G. Hermanson, A. Pokora, Melissa Vermillion   +5 more
semanticscholar   +1 more source

Considerations for the design of antibody drug conjugates (ADCs) for clinical development: lessons learned

Journal of Hematology & Oncology, 2023
Antibody–drug conjugates (ADCs) have emerged as a novel therapeutic strategy that has successfully reached patient treatment in different clinical scenarios.
Alfonso López de Sá, Cristina Díaz-Tejeiro, Elisa Poyatos-Racionero, Cristina Nieto-Jiménez, Lucía Paniagua-Herranz, Adrián Sanvicente, Emiliano Calvo, Pedro Pérez-Segura, Víctor Moreno, Francisco Moris, Alberto Ocana   +10 more
doaj   +1 more source

Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells [PDF]

, 2019
In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.
Baiocco, P., Boffi, A., Bonamore, A., Fazi, F., Macone, A., Masciarelli, S., Palombarini, Federica, Quaglio, D., Trabuco, M. C.   +8 more
core   +2 more sources

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]

, 2016
Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B, Brunsvik Frediksen, A, Grodeland, G, Kinnear, E, Lambert, L, Lindberg, MM, Mcdonald, JU, Stubsrud, E, Tregoning, JS   +8 more
core   +6 more sources

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies [PDF]

, 2013
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trahtenherts, A Walker, Adam Walker, AM Wu, Armin Sepp, B Saunier, C. Andrew Boswell, CL Van Broekhoven, Clare Mudd, DJ Peng, DY Yang, E Dieperink, Edward Coulstock, ES Ward, F Pacifico, G Dusheiko, Gráinne Dunlevy, Jane Sosabowski, Jerome Burnet, JH Park, Julie Foster, KA Deal, Laura Goodall, LC Platanias, LJ Holt, LJ Holt, M Abe, M Loignon, M Spiess, Marie Davies, Milan Ovečka, MW Fried, MW Fried, P Kallinteri, R Duncan, R Gay, R Iorio, Rob Prince, T Eto, U Iyer, U Treichel, WM Pardridge, XQ Zhang, Y Zhang, YI Jeong, YY Seow   +45 more
core   +3 more sources

HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers.

Cancer Discovery, 2020
Amplification and oncogenic mutations of ERBB2, the gene encoding the HER2 receptor tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate that HER2 ubiquitination and internalization, rather than its overexpression, are ...
Bob T. Li, F. Michelini, S. Misale, E. Cocco, L. Baldino, Yanyan Cai, Sophie G. Shifman, H. Tu, Mackenzie L Myers, Chongrui Xu, M. Mattar, I. Khodos, M. Little, B. Qeriqi, G. Weitsman, Clare Wilhelm, A. Lalani, I. Diala, R. Freedman, N. Lin, D. Solit, M. Berger, P. Barber, T. Ng, M. Offin, J. Isbell, David R. Jones, H. Yu, S. Thyparambil, W. Liao, A. Bhalkikar, F. Cecchi, D. Hyman, Jason S. Lewis, Darren J Buonocore, A. Ho, V. Makker, J. Reis-Filho, P. Razavi, M. Arcila, M. Kris, J. Poirier, R. Shen, J. Tsurutani, G. Ulaner, E. de Stanchina, N. Rosen, C. Rudin, M. Scaltriti   +48 more
semanticscholar   +1 more source

Antibody–Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization

Molecular Cancer Therapeutics, 2021
Antibody–drug conjugates (ADC) are a targeted cancer therapy that utilize the specificity of antibodies to deliver potent drugs selectively to tumors.
Samantha N Buongervino, M. Lane, Emily Garrigan, D. Zhelev, D. Dimitrov, K. Bosse   +5 more
semanticscholar   +1 more source

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion [PDF]

, 2018
Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ...
Bouzos, Evangelia, Chau, Huong, Farias, Chantell, Hemingway, Cecilia, Lyman, Roman, Mahacek, Anne, Mobed-Miremadi, Maryam   +6 more
core   +3 more sources