Results 81 to 90 of about 745,289 (215)
Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model [PDF]
, 2017 BACKGROUND: The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood–brain barrier when administered systemically. In this article, we describe the in vitro and
Asby, D. J. +9 more
core +2 more sources
Cancer Research, 2016 Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood.
Fu Li +10 more
semanticscholar +1 more source
Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus. [PDF]
, 2018 The incidence of adverse effects and pathogen resistance encountered with small molecule antibiotics is increasing. As such, there is mounting focus on immunogene therapy to augment the immune system's response to infection and accelerate healing.
Kang, Jinyoung +5 more
core +1 more source
Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy. [PDF]
, 2019 Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target
Bivona, Trever G +8 more
core +1 more source
Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]
, 2020 β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik +4 more
core +2 more sources
Scientific Reports, 2018 Synthetic pyrrolobenzodiazepine (PBD) dimers, where two PBD monomers are linked through their aromatic A-ring phenolic C8-positions via a flexible propyldioxy tether, are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity ...
J. Hartley +17 more
semanticscholar +1 more source
Blood Advances, 2018 : The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus
Yelena Kovtun +16 more
doaj +1 more source
Therapeutic Delivery Technology and its Economic Impact [PDF]
, 2019 Therapeutic delivery technology is a current area of high interest in both university and industrial settings. These technologies are being developed in order to deliver therapeutic agents, such as genes, proteins, and drugs, to patients more efficiently.
Savas, Paul E., Jr.
core +1 more source
Synchronized cycles of bacterial lysis for in vivo delivery [PDF]
, 2016 The pervasive view of bacteria as strictly pathogenic has given way to an ppreciation of the widespread prevalence of beneficial microbes within the human body. Given this milieu, it is perhaps inevitable that some bacteria would evolve to preferentially
A Prindle +38 more
core +2 more sources
New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling [PDF]
, 2017 Antibody-drug conjugates (ADCs) are emerging as a promising class of selective drug delivery systems in the battle against cancer and other diseases.
Ekholm, Filip S. +2 more
core +2 more sources