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Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker, Mads Hald Andersen, Per thor Straten, David Schrama   +3 more
openaire   +3 more sources

A rare case of aggressive cytotoxic T-cell lymphoma in a patient on dupilumab [PDF]

JAAD Case Reports, 2022
Renat Ahatov, BSA, Allison J. Good, MD, Michael Joo, MD, Shelby Tipton, MD, Brandon Goodwin, MD, Brent Kelly, MD   +5 more
doaj   +2 more sources

Heterogeneity of memory T cells in aging

Frontiers in Immunology, 2023
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain, Ines Sturmlechner, Cornelia M. Weyand, Cornelia M. Weyand, Jörg J. Goronzy, Jörg J. Goronzy, Jörg J. Goronzy   +6 more
doaj   +1 more source

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity [PDF]

Nature Communications, 2021
AbstractLethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “additive cytotoxicity” by which time-dependent integration of sublethal damage events ...
Carl G. Figdor, Peter Friedl, Peter Friedl, Harry Dolstra, Annemieke Th den Boer, Bettina Weigelin, Esther Wagena, Johannes Textor, Kelly Broen, Rob J. de Boer   +9 more
openaire   +9 more sources

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

Frontiers in Immunology, 2022
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Jay W. Shin, Takanori Kanai   +22 more
doaj   +1 more source

Cytotoxic CD4 T cells in the mucosa and in cancer

Frontiers in Immunology, 2023
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh, Hrishi Venkatesh, Sean I. Tracy, Sean I. Tracy, Michael A. Farrar, Michael A. Farrar   +5 more
doaj   +1 more source

Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8+ T lymphocytes against Leishmania major [PDF]

BioImpacts, 2023
Introduction: Induction of a protective immune response against Leishmania major requires the activation of both TH1 and CD8+ T lymphocytes. Because L. major is an intra-phagosomal parasite, its antigens do not have access to MHC-I.
Fatemeh Beyzay, Ahamad Zavaran Hosseini, Ali Hazrati, Mozhdeh Karimi, Sara Soudi   +4 more
doaj   +1 more source

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. [PDF]

PLoS Pathogens, 2008
High affinity antigen-specific T cells play a critical role during protective immune responses. Epitope enhancement can elicit more potent T cell responses and can subsequently lead to a stronger memory pool; however, the molecular basis of such ...
Noah S Butler, Alex Theodossis, Andrew I Webb, Roza Nastovska, Sri Harsha Ramarathinam, Michelle A Dunstone, Jamie Rossjohn, Anthony W Purcell, Stanley Perlman   +8 more
doaj   +1 more source

Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1

Frontiers in Immunology, 2022
Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM).
Yukie Tanaka, Yukie Tanaka, Tomoo Sato, Tomoo Sato, Naoko Yagishita, Junji Yamauchi, Junji Yamauchi, Natsumi Araya, Satoko Aratani, Satoko Aratani, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Misako Nagasaka, Yoshinobu Kanda, Yoshinobu Kanda, Kaoru Uchimaru, Kaoru Uchimaru, Tomohiro Morio, Yoshihisa Yamano, Yoshihisa Yamano   +20 more
doaj   +1 more source

Cytotoxic T cells and mycobacteria [PDF]

FEMS Microbiology Letters, 2001
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
Célio Lopes Silva, Alexandrina Sartori, Vânia Luiza Deperon Bonato, Karla De Melo Lima, Lúcia Helena Faccioli, Sylvia Cardoso Leão, Ana O. de Souza, Arlete Aparecida Martins Coelho-Castelo   +7 more
openaire   +3 more sources