Results 1 to 10 of about 2,869,014 (305)

Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response.
Jelle de Wit   +6 more
doaj   +20 more sources

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

open access: yesPLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong   +9 more
doaj   +9 more sources

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation [PDF]

open access: yesFrontiers in Immunology, 2022
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients treated ...
Emily J. Lelliott   +20 more
doaj   +4 more sources

Cytotoxic T-cell immunity to influenza.

open access: yesNew England Journal of Medicine, 1983
In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus.
A. McMichael   +3 more
semanticscholar   +4 more sources

Cytotoxic T Cells [PDF]

open access: yesJournal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker   +3 more
openaire   +3 more sources

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity [PDF]

open access: yesNature Communications, 2021
AbstractLethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “additive cytotoxicity” by which time-dependent integration of sublethal damage events ...
Carl G. Figdor   +9 more
openaire   +9 more sources

Heterogeneity of memory T cells in aging

open access: yesFrontiers in Immunology, 2023
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain   +6 more
doaj   +1 more source

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

open access: yesFrontiers in Immunology, 2022
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto   +22 more
doaj   +1 more source

Cytotoxic CD4 T cells in the mucosa and in cancer

open access: yesFrontiers in Immunology, 2023
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh   +5 more
doaj   +1 more source

A rare case of aggressive cytotoxic T-cell lymphoma in a patient on dupilumab [PDF]

open access: yesJAAD Case Reports, 2022
Renat Ahatov, BSA   +5 more
doaj   +2 more sources

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