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Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald, Schrama, David, thor Straten, Per, Becker, Jürgen C.   +3 more
  +7 more sources

Heterogeneity of memory T cells in aging

Frontiers in Immunology, 2023
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain, Ines Sturmlechner, Cornelia M. Weyand, Cornelia M. Weyand, Jörg J. Goronzy, Jörg J. Goronzy, Jörg J. Goronzy   +6 more
doaj   +1 more source

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

Frontiers in Immunology, 2022
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Jay W. Shin, Takanori Kanai   +22 more
doaj   +1 more source

Cytotoxic CD4 T cells in the mucosa and in cancer

Frontiers in Immunology, 2023
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh, Hrishi Venkatesh, Sean I. Tracy, Sean I. Tracy, Michael A. Farrar, Michael A. Farrar   +5 more
doaj   +1 more source

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. [PDF]

PLoS Pathogens, 2008
High affinity antigen-specific T cells play a critical role during protective immune responses. Epitope enhancement can elicit more potent T cell responses and can subsequently lead to a stronger memory pool; however, the molecular basis of such ...
Noah S Butler, Alex Theodossis, Andrew I Webb, Roza Nastovska, Sri Harsha Ramarathinam, Michelle A Dunstone, Jamie Rossjohn, Anthony W Purcell, Stanley Perlman   +8 more
doaj   +1 more source

Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. [PDF]

PLoS ONE, 2013
Existing approaches that quantify cytotoxic T cell responses rely on bulk or surrogate measurements which impede the direct identification of single activated T cells of interest.
Thomas A Zangle, Daina Burnes, Colleen Mathis, Owen N Witte, Michael A Teitell   +4 more
doaj   +1 more source

Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients

mBio, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier, Krystallenia Paniskaki, Zehra Karaköse, Tanja Werner, Kathrin Sutter, Sebastian Dolff, Marvin Overbeck, Andreas Limmer, Jia Liu, Xin Zheng, Thorsten Brenner, Marc M. Berger, Oliver Witzke, Mirko Trilling, Mengji Lu, Dongliang Yang, Nina Babel, Timm Westhoff, Ulf Dittmer, Gennadiy Zelinskyy   +19 more
doaj   +1 more source

Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1

Frontiers in Immunology, 2022
Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM).
Yukie Tanaka, Yukie Tanaka, Tomoo Sato, Tomoo Sato, Naoko Yagishita, Junji Yamauchi, Junji Yamauchi, Natsumi Araya, Satoko Aratani, Satoko Aratani, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Misako Nagasaka, Yoshinobu Kanda, Yoshinobu Kanda, Kaoru Uchimaru, Kaoru Uchimaru, Tomohiro Morio, Yoshihisa Yamano, Yoshihisa Yamano   +20 more
doaj   +1 more source

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

PLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong, Matthew C Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C Ignacio, Theresa Russell, Satish K Pillai, David J Looney, Satya Dandekar   +9 more
doaj   +1 more source

Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy

Frontiers in Bioengineering and Biotechnology, 2022
Objectives: Evaluation of the feasibility of SARS-CoV-2-specific T cell manufacturing for adoptive T cell transfer in COVID-19 patients at risk to develop severe disease.Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of ...
Agnes Bonifacius, Sabine Tischer-Zimmermann, Maria Michela Santamorena, Philip Mausberg, Josephine Schenk, Stephanie Koch, Johanna Barnstorf-Brandes, Nina Gödecke, Jörg Martens, Lilia Goudeva, Murielle Verboom, Jana Wittig, Jana Wittig, Britta Maecker-Kolhoff, Herrad Baurmann, Caren Clark, Olaf Brauns, Martina Simon, Peter Lang, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Michael Hallek, Rainer Blasczyk, Dominic Seiferling, Philipp Köhler, Philipp Köhler, Britta Eiz-Vesper   +28 more
doaj   +1 more source