Results 1 to 10 of about 2,869,113 (404)

Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. [PDF]

PLoS ONE, 2010
BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response.
Jelle de Wit, Yuri Souwer, Tineke Jorritsma, Hanny Klaasse Bos, Anja ten Brinke, Jacques Neefjes, S Marieke van Ham   +6 more
doaj   +20 more sources

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

PLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong, Matthew C Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C Ignacio, Theresa Russell, Satish K Pillai, David J Looney, Satya Dandekar   +9 more
doaj   +9 more sources

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation [PDF]

Frontiers in Immunology, 2022
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients treated ...
Emily J. Lelliott, Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Mark R. Dowling, Carolyn Shembrey, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Conor J. Kearney, Jessica Michie, Ian A. Parish, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Amelia J. Brennan, Jane Oliaro, Jane Oliaro   +20 more
doaj   +4 more sources

Cytotoxic T-cell immunity to influenza.

New England Journal of Medicine, 1983
In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus.
A. McMichael, F. Gotch, G. Noble, P. Beare   +3 more
semanticscholar   +4 more sources

Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker, Mads Hald Andersen, Per thor Straten, David Schrama   +3 more
openaire   +3 more sources

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity [PDF]

Nature Communications, 2021
AbstractLethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “additive cytotoxicity” by which time-dependent integration of sublethal damage events ...
Carl G. Figdor, Peter Friedl, Peter Friedl, Harry Dolstra, Annemieke Th den Boer, Bettina Weigelin, Esther Wagena, Johannes Textor, Kelly Broen, Rob J. de Boer   +9 more
openaire   +9 more sources

Heterogeneity of memory T cells in aging

Frontiers in Immunology, 2023
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain, Ines Sturmlechner, Cornelia M. Weyand, Cornelia M. Weyand, Jörg J. Goronzy, Jörg J. Goronzy, Jörg J. Goronzy   +6 more
doaj   +1 more source

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

Frontiers in Immunology, 2022
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Jay W. Shin, Takanori Kanai   +22 more
doaj   +1 more source

Cytotoxic CD4 T cells in the mucosa and in cancer

Frontiers in Immunology, 2023
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh, Hrishi Venkatesh, Sean I. Tracy, Sean I. Tracy, Michael A. Farrar, Michael A. Farrar   +5 more
doaj   +1 more source

A rare case of aggressive cytotoxic T-cell lymphoma in a patient on dupilumab [PDF]

JAAD Case Reports, 2022
Renat Ahatov, BSA, Allison J. Good, MD, Michael Joo, MD, Shelby Tipton, MD, Brandon Goodwin, MD, Brent Kelly, MD   +5 more
doaj   +2 more sources