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Cytotoxic T-Cell Immunity to Influenza
New England Journal of Medicine, 1983 In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus. Over the next seven days clinical observations were made, and the amount of virus shed was measured.
Mcmichael, A +3 more
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Journal of Investigative Dermatology, 2006 The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker +3 more
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Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity [PDF]
Nature Communications, 2021 AbstractLethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “additive cytotoxicity” by which time-dependent integration of sublethal damage events ...
Carl G. Figdor +9 more
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Heterogeneity of memory T cells in aging
Frontiers in Immunology, 2023 Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain +6 more
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Frontiers in Immunology, 2022 Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto +22 more
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Cytotoxic CD4 T cells in the mucosa and in cancer
Frontiers in Immunology, 2023 CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh +5 more
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Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. [PDF]
PLoS Pathogens, 2008 High affinity antigen-specific T cells play a critical role during protective immune responses. Epitope enhancement can elicit more potent T cell responses and can subsequently lead to a stronger memory pool; however, the molecular basis of such ...
Noah S Butler +8 more
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Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. [PDF]
PLoS ONE, 2013 Existing approaches that quantify cytotoxic T cell responses rely on bulk or surrogate measurements which impede the direct identification of single activated T cells of interest.
Thomas A Zangle +4 more
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Cytotoxic T cells and mycobacteria [PDF]
FEMS Microbiology Letters, 2001 How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
Célio Lopes Silva +7 more
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Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
mBio, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier +19 more
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