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Cytotoxic T cells – Stroma interactions
Bulletin du Cancer, 2011The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators ...
Muhammad Zaeem, Noman +3 more
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Current Opinion in Immunology, 2008
The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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Human mucosal T-cell cytotoxicity
Gastroenterology, 1988Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from noninflamed human colonic mucosa. Anti-
F, Shanahan +4 more
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T-cell mediator induction of non-T-cell cytotoxicity
Cellular Immunology, 1976Publisher Summary This chapter focuses on the nonspecific lymphocyte cytotoxicity for allogeneic target cells, also termed spontaneous cytotoxicity or background cytotoxicity reported by several investigators studying graft rejection and tumor immunology phenomena.
Peggy A. O'Neill, Bruce F. Mackler
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Tumor Infiltrating T Cell Cytotoxicity Assay
2021Cytotoxicity is the primary function of CD8+ T-cells, also called cytotoxic CD8+ T lymphocytes (or CTLs). Quantification of this capacity is of major importance in diagnostic and research tools. While phenotypic characterization of CTLs is frequent and easily performed, their function is indeed more difficult to assess.
Nada, Chaoul, Marcello, Albanesi
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Cytotoxic T-cell memory without antigen
Nature, 1994Memory is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained. The current model is that long-term memory is dependent on persistent antigenic stimulation. We report here results that challenge this view and provide evidence that antigen is not essential for the
L L, Lau +3 more
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Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004
Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways.
Ge, Ma, Li-ping, Zhu, Wei, Zhang
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Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways.
Ge, Ma, Li-ping, Zhu, Wei, Zhang
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Herpesvirus-transformed cytotoxic T-cell lines
Nature, 1981Investigations of cellular cytotoxicity of the immune system are hampered by the lack of continuously growing, transformed cell lines which express a cytotoxic potential. Here we describe cytotoxic cell lines from the cotton-topped marmoset monkey, transformed by Herpesvirus Ateles (HVA) or Herpesvirus Saimiri (HVS), which can kill certain target cells
D R, Johnson, M, Jondal
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Enumeration of specific cytotoxic T cells
Nature, 1976EFFORTS directed towards the enumeration of effector cells involved in the cell-mediated immune response have so far met with little success. One of the principal reasons for this failure is the current ignorance of relationships between killer, lymphokine producer and suppressor T cells, all of which have effector functions.
Thorn, R M, Henney, C S
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Cytotoxic T cells in teleost fish
Developmental & Comparative Immunology, 2011The presence of antigen-specific cytotoxic T cells has been suggested in a number of in vivo and in vitro studies in fish. Acute allograft rejection with an accelerated response on second-set grafts and the presence of graft-versus-host reaction (GVHR) has been reported in teleost. Alloantigen- and virus-specific cytotoxicity has also been demonstrated
Teruyuki, Nakanishi +3 more
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