Results 131 to 140 of about 733,847 (374)

Effects of Exogenous Enzymes and Salix babylonica L. Extract on Cellular Immune Response and its Correlation with Average Daily Weight Gain in Growing Lambs [PDF]

, 2013
The aim of this study was to determine the effects of exogenous enzyme (EZ) and Salix babylonica L. (SB) extract on cellular immune response, and its correlation with average daily weight gain (ADG).
CAMACHO DIAZ, LUIS MIGUEL, CAMACHO DIAZ, LUIS MIGUEL, CERRILLO SOTO, MARIA ANDREA, CERRILLO SOTO, MARIA ANDREA, GADO, HANY.M., GADO, HANY.M., González Ronquillo, Manuel, González Ronquillo, Manuel, PEÑUELAS RIVAS, CLAUDIA GIOVANNA, PEÑUELAS RIVAS, CLAUDIA GIOVANNA, Rivero Navarro, Miguel Ángel, Rivero Navarro, Miguel Ángel, Zeidan Mohamed Salem, Abdelfattah, Zeidan Mohamed Salem, Abdelfattah   +13 more
core  

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia

Haematologica, 2009
Background T-cell large granular lymphocytic leukemia is a clonal proliferation of cytotoxic T-lymphocytes which often results in severe cytopenia. Current treatment options favor chronic immunosuppression.
Sanjay R. Mohan, Michael J. Clemente, Manuel Afable, Heather N. Cazzolli, Nelli Bejanyan, Marcin W. Wlodarski, Alan E. Lichtin, Jaroslaw P. Maciejewski   +7 more
doaj   +1 more source

Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes [PDF]

, 2010
Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus.
Grynyuk, I.I., Matyshevska, O.P., Palyvoda, K.O., Prylutska, S.V.   +3 more
core  

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance None of the single-cell RNA sequencing (scRNA-seq) studies published so far convincingly identified human γδ T lymphocytes despite their anticancer functions.
Gabriele Pizzolato, H. Kaminski, M. Tosolini, D. Franchini, F. Pont, Frédéric Martins, Carine Valle, Delphine Labourdette, Sarah Cadot, A. Quillet-Mary, M. Poupot, C. Laurent, L. Ysebaert, S. Meraviglia, F. Dieli, P. Merville, P. Milpied, J. Déchanet-Merville, J. Fournié   +18 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America, 1985
Influenza A virus-specific cytotoxic T lymphocytes (CTL) capable of lysing cells infected with any influenza A virus ("cross-reactive CTL") constitute a major portion of the host CTL response to influenza.
J. Yewdell, J. Bennink, G. Smith, B. Moss   +3 more
semanticscholar   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

Proceedings of the National Academy of Sciences of the United States of America, 1982
Alloreactive human T lymphocytes were cloned in soft agar or by limiting dilution and subsequently propagated with interleukin 2 and alloantigen for 8 months or more. By indirect immunofluorescence every clone was reactive with anti-Ia antibodies as well
S. Meuer, S. Schlossman, E. Reinherz
semanticscholar   +1 more source