Results 151 to 160 of about 358,425 (341)
Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy
Advanced Science, EarlyView.After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li +6 morewiley +1 more sourceThree‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy
Advanced Science, EarlyView.Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract
The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin +14 morewiley +1 more sourceA High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing
, 2018 Patrick H. Lizotte, Ruey‐Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Meghana Kulkarni, Lauren Badalucco, Erica Fitzpatrick, Hsiang‐Fong Kao, Mari Kuraguchi, Mark Bittinger, Paul T. Kirschmeier, Nathanael S. Gray, David A. Barbie, Pasi A. Jänne +18 moreopenalex +2 more sourcesExtracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen +5 morewiley +1 more sourceCytotoxic T-Lymphocyte Escape Does Not Always Explain the Transient Control of Simian Immunodeficiency Virus SIVmac239 Viremia in Adenovirus-Boosted and DNA-Primed Mamu-A*01-Positive Rhesus Macaques
, 2005 Adrian B. McDermott, David H. O’Connor, Sarah Fuenger, Shari M. Piaskowski, Sarah R. Martin, John T. Loffredo, Matthew R. Reynolds, Jason S. Reed, Jessica Furlott, Timothy J. Jacoby, Cara Riek, Elizabeth Dodds, Kendall Krebs, Mary-Ellen Davies, William A. Schleif, Danilo R. Casimiro, John W. Shiver, David I. Watkins +17 moreopenalex +1 more sourceRapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost [PDF]
, 2005 Caroline S. Fernandez, Ivan Stratov, Robert De Rose, Katrina A. Walsh, C. Jane Dale, Miranda Z. Smith, Michael B. Agy, Shiu‐Lok Hu, Kendall Krebs, David I. Watkins, David H. O’Connor, Miles P. Davenport, Stephen J. Kent +12 moreopenalex +1 more sourceA Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer
Advanced Science, EarlyView.Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari +11 morewiley +1 more sourceEffect Of Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) Haplotype On Allogeneic Hematopoietic Stem Cell Transplantation
, 2010 Masaki Murase, Tetsuya Nishida, Makoto Onizuka, Yoshihiro Inamoto, Kyoko Sugimoto, N. Imahashi, Makoto Murata, Koichi Miyamura, Y Kodera, Hidetoshi Inoko, T Naoe +10 moreopenalex +1 more source
