Results 251 to 260 of about 358,425 (341)

TYK2 signaling promotes the development of autoreactive CD8⁺ cytotoxic T lymphocytes and type 1 diabetes. [PDF]

Nat Commun
Mine K, Nagafuchi S, Akazawa S, Abiru N, Mori H, Kurisaki H, Shimoda K, Yoshikai Y, Takahashi H, Anzai K.   +9 more
europepmc   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

The potential role of CD8+ cytotoxic T lymphocytes and one branch connected with tissue-resident memory in non-luminal breast cancer. [PDF]

PeerJ
Zhao Z, Ma X, Cai Z.
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Correction: The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency [PDF]

Prabha Chandrasekaran, Máté Krausz, Yu Han, Noriko Mitsuiki, Annemarie Gabrysch, Christina Nöltner, Michele Proietti, Theo Heller, Caroline Grou, Virginie Calderon, Poorani Subramanian, Drew R. Jones, Yik Siu, Clayton Deming, Sean Conlan, Steven M. Holland, Julia A. Segre, Gülbu Uzel, Bodo Grimbacher, Emilia Liana Falcone   +19 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Establish a novel immune-related gene prognostic risk index (IRGPRI) associated with CD8+ cytotoxic T lymphocytes in non-small-cell lung cancer (NSCLC). [PDF]

Heliyon
Cui S, Yang Y, Lou S, Huang R, Wang J, Chen Z, Xie J.   +6 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing. [PDF]

Nat Commun
Zhou Y, Wang D, Zhou L, Zhou N, Wang Z, Chen J, Pang R, Fu H, Huang Q, Dong F, Cheng H, Zhang H, Tang K, Ma J, Lv J, Cheng T, Fiskesund R, Zhang X, Huang B.   +18 more
europepmc   +1 more source