Results 281 to 290 of about 358,425 (341)

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

Advanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang, Wenfei Xu, Yuechen Liu, Shuxuan Zhu, Wenjing Liu, Shuhui Bo, Hong Sun, Bei Liu, Zhaogang Sun, Hongqian Chu   +9 more
wiley   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva [PDF]

, 1995
Goddeeris, Bruno, Morrison, Ivan, Morzaria, S P, Taracha, Evans L. N.   +3 more
core  

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Upregulated Circulating CD4 KLRD1 T Cells Exhibit Characteristics of CD4 Cytotoxic T Lymphocytes in Systemic Lupus Erythematosus Patients

Qi Li, Zihang Yuan, Ayibaota Bahabayi, Sen Zhou, Guochong Wang, Zhonghui Zhang, Ziqi Xiong, Qinzhu Xu, Pingzhang Wang, Chen Liu   +9 more
openalex   +1 more source

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Cytotoxic T-lymphocytes.

Advances in internal medicine, 1988
Cytotoxic T-lymphocytes have received intensive scrutiny in the past decade, and have been implicated as important effector cells in diverse clinical settings. A variety of technological advances--the establishment of T cell clones, the production of MAb, the production of pure lymphokines through gene cloning, the modification of target cells by gene ...
S, Martin, E, Cantin, B T, Rouse
openaire   +4 more sources

Suppressor‐Cytotoxic T‐Lymphocyte Panniculitis

Pediatric Dermatology, 1986
Abstract: A 3½‐year‐old girl had fever and nonsuppurative panniculitis. Biopsies revealed lobular lymphocytic panniculitis. An extensive evaluation of the patient for infectious and other systemic diseases yielded negative results. Although the number of peripheral T lymphocytes was normal, suppressor‐cytotoxic (0KT8) lymphocytes predominated in the ...
A R, Solomon, A G, Kantak, J E, Ramirez, S, Rajaraman, S S, Raimer, A S, Goldman   +5 more
openaire   +2 more sources

Endocytosis in cytotoxic T-lymphocytes

Cellular Immunology, 1981
Abstract Endocytosis in T lymphocytes was analyzed during their differentiation into cytotoxic effector cells in allogeneic mixed lymphocyte cultures. We found that endocytic activity increases from a very low value to reach a peak at Day 5, at which time the cytotoxic titer is highest in these cell cultures.
Heiniger, H J, Sodergren, A, Marshall, J D   +2 more
openaire   +2 more sources