Results 301 to 310 of about 733,847 (374)

Bifidobacterium animalis subsp. lactis modulates early‐life immune response and gut metabolism

Animal Models and Experimental Medicine, EarlyView.
Background: The maturation of the immune system is critical during early life, as it involves the differentiation, maturation, and establishment of immune tolerance of immune cells. This process is influenced not only by genetic factors but also by environmental factors, particularly the symbiotic microbiota. Bifidobacterium animalis subsp.
Haoming Du, Yiran Cai, Lulu Shen, Yuxing Zheng, Lingling Zhao, Ruibiao Hu, Shan Jiang, Jiajia Yuan, Chengming Hu, Qi Deng, Jiaoyan Huang, Jingbo Hu, Yuexiang Wang, Jing Tan, Jiahui Chen, Feitong Liu, Yuanyuan Duan, Haitao Niu   +17 more
wiley   +1 more source

Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation

Advanced NanoBiomed Research, EarlyView.
The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo   +3 more
wiley   +1 more source

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

Arthritis &Rheumatology, EarlyView.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo   +16 more
wiley   +1 more source

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CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

Journal of Cellular Physiology, 2018
CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with ...
Bagher Farhood, M. Najafi, K. Mortezaee
semanticscholar   +1 more source

Cytotoxic Activity of Lymphocytes

The Journal of Immunology, 1972
Abstract Antibody to human lymphotoxin was elicited in rabbits immunized with partially purified supernatants of human spleen cells stimulated by phytohemagglutinin; Anti-LT activity, assayed by neutralizing soluble LT toxicity to indicator mouse L cells, is confined to the immunoglobulin fraction of the serum; it cannot be removed by ...
Sharyn M. Walker, Zoltan J. Lucas
openaire   +1 more source

Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.

Science, 1998
Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load.
G. Ogg, Xia Jin, S. Bonhoeffer, P. Dunbar, M. Nowak, S. Monard, J. Segal, Yun-zhen Cao, S. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. Ho, D. Nixon, A. McMichael   +14 more
semanticscholar   +1 more source

Lymphocyte-Mediated Cytotoxicity

Annual Review of Immunology, 2002
Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that ...
Timothy J. Ley, John H. Russell
openaire   +2 more sources

Endocytosis in cytotoxic T-lymphocytes

Cellular Immunology, 1981
Abstract Endocytosis in T lymphocytes was analyzed during their differentiation into cytotoxic effector cells in allogeneic mixed lymphocyte cultures. We found that endocytic activity increases from a very low value to reach a peak at Day 5, at which time the cytotoxic titer is highest in these cell cultures.
Heiniger, H J, Sodergren, A, Marshall, J D   +2 more
openaire   +3 more sources

T lymphocytes with promiscuous cytotoxicity

Nature, 1976
CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1.
Chaim Shustik, Irun R. Cohen, Irun R. Cohen, Elizabeth Latham-Griffin, Robert S. Schwartz, S D Waksal   +5 more
openaire   +3 more sources

Cytotoxic T lymphocytes and autoimmunity

Current Opinion in Rheumatology, 2005
The possibility of the recognition by cytotoxic T lymphocytes of tissue autoantigens has been largely ignored in explaining organ-specific autoimmune diseases. Recent advances in the understanding of human leukocyte antigen class I-binding peptides motifs have led to the detection and the characterization of those autoreactive CD8(+) cytotoxic T ...
Patrick Blanco, Jean-Luc Pellegrin, Jean-François Viallard, Jean-François Moreau   +3 more
openaire   +3 more sources