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Virus-Neuron-Cytotoxic T Lymphocyte Interactions
1995Neurons have evolved unique strategies to evade immune recognition which allow viruses to infect and persist, yet resist attack by antiviral cytotoxic T lymphocytes (CTLs). However, the ability of activated CTLs to percolate through the normal central nervous system (CNS) (Hickey et al.
G F, Rall, M B, Oldstone
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Radiosensitivity of Murine T-Lymphocyte Cytotoxicity
Radiation Research, 1984A biphasic curve was observed when surviving allogeneic lytic activity was plotted as a function of irradiation delivered before sensitization. Flow cytometry analysis demonstrated that the number of cells was reduced in response to increasing dose and that subset precursors Lyt 1+2+ were proportionally more radiosensitive than the other subsets ...
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Cytotoxic T-Lymphocyte–Associated Antigen-4
Clinical Cancer Research, 2007Abstract Previously, the development of immune-based therapies has primarily focused on vaccines and cytokines, yielding benefit in a small percentage of patients. Recent advances in our understanding of the function of costimulatory molecules have revitalized enthusiasm in the development of immune therapies for cancer.
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Cytotoxic T lymphocyte mediated cytolysis
Biochemistry, 1988J, Tschopp, C V, Jongeneel
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Science, 2020Zhiwei Zhou, Huabin He, Yupeng Wang
exaly