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Studies on the Cytotoxicity of Lymphocytes [PDF]

, 1969
The higher organisms are equipped with two different systems for immunological defence. One system is characterized by the production of humoral antibodies, the other by the appearence of specifically sensitized lymphocytes, which are capable of direct interaction with the antigen.
W. Ax, H. Fischer, I. Zeiss, H. Malchow
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Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

Science, 1998
CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses.
Ruobing Wang, D. Doolan, T. P. Le, R. Hedstrom, K. Coonan, Y. Charoenvit, T. Jones, P. Hobart, M. Margalith, Jennifer Ng, W. Weiss, M. Sedegah, C. Taisne, J. Norman, S. Hoffman   +14 more
semanticscholar   +1 more source

The stepwise activation of cytotoxic T lymphocytes

Immunology Today, 1987
The recognition of antigen is the first stage of T-lymphocyte maturation in vivo. Monoclonal antibodies directed against the T-cell receptor/CD3 complex and against other surface antigens can also provide this stimulus. Gianni Gromo and his colleagues are attempting to characterize the steps leading from this initial activation to full functional ...
R. L. Geller, Fritz H. Bach, Luca Inverardi, Gianni Gromo, Barbara J. Alter   +4 more
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The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes

1985
Three years ago, at the First Workshop on Mechansisms of Cell-Mediated Cytotoxicity, we presented a summary of the evidence developed in our lab that the ADCC and NK cytotoxic functions of large granular lymphocytes (LGL) operated via a secretory process (1).
Pierre A. Henkart, Maryanna Henkart, Peter H. Frederikse, Paul J. Millard, Craig W. Reynolds, Cho Yue, Robert Blumenthal, Jeff Bluestone   +7 more
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Suppressor‐Cytotoxic T‐Lymphocyte Panniculitis

Pediatric Dermatology, 1986
Abstract: A 3½‐year‐old girl had fever and nonsuppurative panniculitis. Biopsies revealed lobular lymphocytic panniculitis. An extensive evaluation of the patient for infectious and other systemic diseases yielded negative results. Although the number of peripheral T lymphocytes was normal, suppressor‐cytotoxic (0KT8) lymphocytes predominated in the ...
Jaime E. Ramirez, Srinivasan Rajaraman, Anand G. Kantak, Armond S. Goldman, Sharon S. Raimer, Alvin R. Solomon   +5 more
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science, 2020
Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, W. Han, L. Shen, Jingjin Ding, F. Shao   +14 more
semanticscholar   +1 more source

Cytotoxic Lymphocytes

1979
Publisher Summary This chapter discusses cytotoxic lymphocytes. Evaluation of the biological significance of the results of an in vitro assay is critically dependent on the correct assessment of the many limitations of the assay. Lymphocytes are mixed with proper target cells, and the ensuing damage of the latter is measured after incubation under ...
Peter Perlmann, Jean-Charles Cerottini
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Inhibition of cytotoxic T lymphocytes with concanavalin A

Cellular Immunology, 1980
Abstract Increasing concentrations of concanavalin A (ConA) were found to increasingly inhibit immunologically specific cytotoxic T lymphocyte (CTL)-mediated cytolysis. Even concentrations of ConA that best enabled nonspecific cytolysis were found to inhibit immunologically specific cytolysis by the same population of effector cells.
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Cytotoxic T lymphocytes against HIV

AIDS, 1990
HIV-1 infection has clearly been shown to induce a vigorous CTL response in infected people, and this response is present at a time when immune function otherwise is globally impaired. HIV-1-specific CTL are detectable both in peripheral blood and tissues of infected people, and are aimed at multiple viral proteins.
Bruce D. Walker, Fernando Plata
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Cytotoxic Lymphocytes and Cardiac Electrophysiology

Journal of Molecular and Cellular Cardiology, 2002
It is widely recognized that immune effector mechanisms contribute to cardiac dysfunction in major cardiac pathologies, such as myocarditis and the consequent dilated cardiomyopathy, Chagas' disease and heart transplant rejection. Of the wealth of immune mechanisms known to affect cardiac function, this review will deal with the adverse effects caused ...
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