Identification of a Novel CD160+CD4+ T-Lymphocyte Subset in the Skin: A Possible Role for CD160 in Skin Inflammation [PDF]
, 2007 CD160 is a glycosylphosphatidylinositol-anchored cell surface molecule expressed by human circulating cytotoxic lymphocytes that correspond to the majority of natural killer cell (NK) expressing CD56dim, TCRγδ lymphocytes, and to a minor CD8 T-cell ...
Abecassis, Sofia +7 more
core +1 more source
Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses [PDF]
, 2012 Human immunodeficiency virus (HIV-1 or simply HIV) induces a persistent infection, which in the absence of treatment leads to AIDS and death in almost all infected individuals. HIV infection elicits a vigorous immune response starting about 2-3 weeks post infection that can lower the amount of virus in the body, but which cannot eradicate the virus ...
arxiv +1 more source
Journal of Experimental Medicine, 1998 This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated β2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33–41) of ...
A. Gallimore +7 more
semanticscholar +1 more source
Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer [PDF]
, 2013 Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
arxiv +1 more source
CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma
Archives of Medical Science, 2023 Introduction The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.
Lu Tang, Hao Jin
doaj +1 more source
Genes predisposing to type 1 diabetes mellitus and pathophysiology: a narrative review [PDF]
arXiv, 2021 The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the interest of all stakeholders ...
arxiv
Search and capture efficiency of dynamic microtubules for centrosome relocation during IS formation [PDF]
Biophysical Journal (2019), 2019 Upon contact with antigen presenting cells (APCs) cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) towards the contact zone, which necessitates a proper connection between MTOC and IS via dynamic ...
arxiv +1 more source
THE FEATURES OF BLOOD IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH VARIOUS FORMS OF BRUCELLOSIS
Инфекция и иммунитет, 2014 . Results of current study have shown that acute brucellosis is characterized by increase of T-helper and cytotoxic T-lymphocytes and decrease of phagocytic activity of neutrophyls in the blood.
O. V. Logvinenko +5 more
doaj +1 more source
Spatiotemporal dynamics of a glioma immune interaction model
Scientific Reports, 2021 We report a mathematical model which depicts the spatiotemporal dynamics of glioma cells, macrophages, cytotoxic-T-lymphocytes, immuno-suppressive cytokine TGF-β and immuno-stimulatory cytokine IFN-γ through a system of five coupled reaction-diffusion ...
Subhas Khajanchi, Juan J. Nieto
doaj +1 more source
Mathematical modeling to elucidate brain tumor abrogation by immunotherapy with T11 target structure [PDF]
, 2014 T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure.
arxiv +1 more source