Results 71 to 80 of about 733,847 (374)

A model of virus infection with immune responses supports boosting CTL response to balance antibody response [PDF]

arXiv, 2022
We analyze a within-host model of virus infection with antibody and CD8+ cytotoxic T lymphocyte (CTL) responses proposed by Schwartz et al. (2013). The goal of this work is to gain an overview of the stability of the biologically-relevant equilibria as a function of the model's immune response parameters. We show that the equilibria undergo at most two
arxiv  

Analysis and optimal control of an intracellular delayed HIV model with CTL immune response [PDF]

Math. Comput. Sci. 12 (2018), no. 2, 111--127, 2018
A delayed model describing the dynamics of HIV (Human Immunodeficiency Virus) with CTL (Cytotoxic T Lymphocytes) immune response is investigated. The model includes four nonlinear differential equations describing the evolution of uninfected, infected, free HIV viruses, and CTL immune response cells.
arxiv   +1 more source

Analysis of Cellular Component Indicators of Immune Status of Rhesus Macaques

Проблемы особо опасных инфекций, 2021
Objective. Selection of indicators of lymphocyte populations in rhesus macaques determined by flow cytometry to evaluate variations of cellular constituent of their immune status.Materials and methods.
G. V. Borisevich, S. L. Kirillova, O. N. Sidorova, V. N. Lebedev, A. A. Petrov, A. V. Ovchinnikov, I. V. Shatokhina, T. E. Sizikova, V. E. Sazonov, E. S. Mukhacheva, S. V. Borisevich   +10 more
doaj   +1 more source

Inflammatory and immune variables as predictors of survival in dogs with myxomatous mitral valve disease

BMC Veterinary Research
Background We aimed to investigate the association between selected inflammatory and immune variables and survival of dogs with myxomatous mitral valve disease (MMVD).
Martina Cimerman, Natalia Druzhaeva, Alenka Nemec Svete, Melita Hajdinjak, Katka Pohar, Alojz Ihan, Aleksandra Domanjko Petrič   +6 more
doaj   +1 more source

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status

Scientific Reports, 2022
Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymphocytes, which
Sana Belkahla, Joaquin Marco Brualla, Alexis Fayd’herbe de Maudave, Paolo Falvo, Nerea Allende-Vega, Michael Constantinides, Abrar Ul Haq Khan, Lois Coenon, Catherine Alexia, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Wissem Mnif, Javier Hernandez, Alberto Anel, Martin Villalba   +16 more
doaj   +1 more source

Impaired CD4+ Cytotoxic T Lymphocyte Activity in Polyomavirus BK Infected Kidney Transplant Recipients

Iranian Journal of Allergy, Asthma and Immunology, 2023
The reactivation of polyomavirus BK (BKPyV) contributes to increased morbidity and mortality rates of transplant patients, especially kidney transplant recipients (KTRs).
Nasrin Noshadi, Ramin Yaghoubi, Afsoon Afshari, Mohsen Forouzanfar, Saeede soleimanian   +4 more
doaj   +1 more source

CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA

Alʹmanah Kliničeskoj Mediciny, 2016
Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed.
E. G. Shuganov, N. A. Raspopina, Zh. M. Salmasi   +2 more
doaj   +1 more source

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

Proceedings of the National Academy of Sciences of the United States of America, 1996
The conventional approach to cytotoxic T-lymphocyte (CTL) induction uses maximal antigen concentration with the intent of eliciting more CTL. However, the efficacy of this approach has not been systematically explored with regard to the quality of the ...
M. Alexander-Miller, G. Leggatt, J. Berzofsky   +2 more
semanticscholar   +1 more source

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Сеченовский вестник
Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures ...
T. M. Kulinich, Ya. Yu. Kiseleva, A. M. Shishkin, E. A. Kudinova, O. B. Knyazeva, R. Ranjit, V. K. Bozhenko, V. A. Solodky   +7 more
doaj   +1 more source

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

Journal of Experimental Medicine, 1998
This study shows that induction of tumor-specific CD4+ T cells by vaccination with a specific viral T helper epitope, contained within a synthetic peptide, results in protective immunity against major histocompatibility complex (MHC) class II negative ...
F. Ossendorp, E. Mengede, M. Camps, Rian Filius, C. Melief   +4 more
semanticscholar   +1 more source