Results 231 to 240 of about 937,918 (334)

Engineering Innate Immunity: Recent Advances and Future Directions for CAR-NK and CAR-Macrophage Therapies in Solid Tumors. [PDF]

Cancers (Basel)
Amoozgar B, Bangolo A, Mansour C, Elias D, Mohamed A, Thor DC, Ehsanullah SU, Tran HH, Aguilar IK, Weissman S.   +9 more
europepmc   +1 more source

Antibody-dependent cellular cytotoxicity and skin disease.

Journal of Investigative Dermatology, 1985
David A. Norris, L. Lee
semanticscholar   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

LIMD2 is associated with an exhausted CD8⁺ T cell state linked to ICI response in clear cell renal cell carcinoma. [PDF]

Sci Rep
Zhang J, Peng Q, Xiang X, Liu F, Jiang X, Nie H, Bi X, Pan T, Li K, Chen P, Yuan S, Chen S.   +11 more
europepmc   +1 more source

Modulation of natural killer cell‐mediated cytotoxicity by tamoxifen and estradiol

Cancer, 1995
E. Baral, É. Nagy, I. Bérczi
semanticscholar   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Carbon dot-lipidoid nanocarriers for superiorly biocompatible nasal mRNA cancer vaccination. [PDF]

J Nanobiotechnology
Kim H, Jeong H, Kim YA, Kim KS, Yun JW, Li F, Ling D, Na K.   +7 more
europepmc   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Desensitization Strategies in Immunized Heart Transplant Recipients.

Eur Surg Res
Goerler A, Kruszona S, Aburahma K, de Manna ND, Salman J, Ruhparwar A, Avsar M, Schmack B, Ius F.   +8 more
europepmc   +1 more source

Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV. [PDF]

Open Forum Infect Dis
Vanpouille C, Wells A, DeGruttola V, Lynch M, Zhang X, Tu XM, Chaillon A, Woodworth B, Gaitan N, Rawlings SA, Landay A, Weber KM, Scully EP, Karn J, Gianella S.   +14 more
europepmc   +1 more source