Results 261 to 270 of about 906,600 (363)

Living Biotherapeutics Using Nanoparticles‐Armed Cyanobacteria for Boosting Photodynamic‐Immunotherapy of Cancer

open access: yesAdvanced Science, EarlyView.
A schematic illustration of the cyanobacteria‐based biohybrid platform for photodynamic cancer therapy enhanced PDT. The platform continuously outputs O2 (to alleviate tumor hypoxia) and 1O2 (for tumor treatment), achieving improved photodynamic immunotherapy. Abstract The interdisciplinary development of synthetic biology and material sciences propels
Zhengwei Xu   +14 more
wiley   +1 more source

Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Transplantation. [PDF]

open access: yesMicroorganisms
Cioni M   +23 more
europepmc   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang   +17 more
wiley   +1 more source

Convertible ROS Nanocatalyst/Eliminator for Enhancing Tumor Radio‐Immunotherapy and Relieving Radiation Enteritis

open access: yesAdvanced Science, EarlyView.
A novel Janus Ag/Ag2S nanostructure grafted with dimer PD‐L1 affibody (AMZ) is successfully developed. AMZ can be used as ROS nanocatalyst to achieve tumor radiosensitization, and it can also act as an ROS eliminator to alleviate radiation enteritis, achieving a radiotherapy strategy characterized by “toxicity reduction and efficacy enhancement ...
Mengmeng Zhang   +12 more
wiley   +1 more source

Targeted CD47 checkpoint blockade using a mesothelin-directed antibody construct for enhanced solid tumor-specific immunotherapy. [PDF]

open access: yesCancer Immunol Immunother
Reischer A   +21 more
europepmc   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang   +11 more
wiley   +1 more source

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