Results 341 to 350 of about 906,600 (363)
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A Reappraisal of Cytotoxic Lymphocytes in Human Tumor Immunology
1987Extensive work done at the Section of Clinical Tumor Virology and Immunology, Department of Medicine, The University of Texas M. D. Anderson Hospital, from 1968 to 1978 on the cytotoxicity of lymphocytes to cultured human tumor cells is reviewed. The early results and concepts are now reinterpreted in the light of newer knowledge generated worldwide in
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HIV-specific cytotoxic T-lymphocyte activity in immunologically normal HIV-infected persons
AIDS, 1998CD8+ T-cell counts usually increase soon after infection with HIV, whereas CD4+ cell counts decrease. The result of these changes in T-cell subpopulation subsets in most HIV-infected subjects is inversion of the CD4 : CD8 ratio from greater than 1.0 typical of uninfected persons to less than 1.0 after infection.Six HIV-infected individuals were ...
Famane Chung +5 more
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Immunological Studies in Human Schistosomiasis
The American Journal of Tropical Medicine and Hygiene, 1977Complement dependent cytotoxic antibodies for Schistosoma mansoni schistosomules were studied in a Brazilian population. The sera of S. mansoni-infected patients gave a high percentage of cytotoxicity (63.4%) compared with sera from persons not infected (8.7%). The IgG class and the specificity of these cytotoxic antibodies are defined.
Capron, Monique +4 more
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International Archives of Allergy and Immunology, 1980
Rabbits immunized with a saline extract of intestinal tissue in complete Freund’s adjuvant produce antibody which mediates complement-dependent cytotoxicity for colon epithelial cells <i>in vitro</i>. The presence of this antibody did not correlate with histologic alterations of the colon in the immunized rabbits.
Ellen Herrington, Bruce S. Rabin
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Rabbits immunized with a saline extract of intestinal tissue in complete Freund’s adjuvant produce antibody which mediates complement-dependent cytotoxicity for colon epithelial cells <i>in vitro</i>. The presence of this antibody did not correlate with histologic alterations of the colon in the immunized rabbits.
Ellen Herrington, Bruce S. Rabin
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Cell-Mediated Cytotoxicity to Muscle in Polymyositis
, 1973Immunologic injury to cultures of skeletal muscle was studied in patients with polymyositis by means of a 51Cr release method that allows quantitation of myocyte injury. Lymphocyte-mediated myotoxicity was elevated in a group of nine patients with active
R. Dawkins, F. Mastaglia
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Critical Reviews in Immunology, 2015
A synapse is a specialized structure that forms when the plasma membrane of two cells come into close contact to facilitate communication and signaling. Cells of the immune system form 'immunological' synapses that have an ordered structure and are essential for immune cell activation, function and homeostasis.
Phillip K. Darcy +3 more
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A synapse is a specialized structure that forms when the plasma membrane of two cells come into close contact to facilitate communication and signaling. Cells of the immune system form 'immunological' synapses that have an ordered structure and are essential for immune cell activation, function and homeostasis.
Phillip K. Darcy +3 more
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Annual Review of Immunology, 1996
Studies with perforin-deficient mice have demonstrated that two independent mechanisms account for T cell–mediated cytotoxicity: A main pathway is mediated by the secretion of the pore-forming protein perforin by the cytotoxic T cell, whereas an alternative nonsecretory pathway relies on the interaction of the Fas ligand that is upregulated during T ...
Rolf M. Zinkernagel +4 more
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Studies with perforin-deficient mice have demonstrated that two independent mechanisms account for T cell–mediated cytotoxicity: A main pathway is mediated by the secretion of the pore-forming protein perforin by the cytotoxic T cell, whereas an alternative nonsecretory pathway relies on the interaction of the Fas ligand that is upregulated during T ...
Rolf M. Zinkernagel +4 more
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, 1988
In postinflammatory hypopigmentation and in vitiligo, one observes histologic evidence of melanocyte damage, disappearance of melanocytes, and clinical loss of pigmentation. In the case of vitiligo, this loss of pigment is complete. There is considerable
D. Norris +6 more
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In postinflammatory hypopigmentation and in vitiligo, one observes histologic evidence of melanocyte damage, disappearance of melanocytes, and clinical loss of pigmentation. In the case of vitiligo, this loss of pigment is complete. There is considerable
D. Norris +6 more
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Immunoselection of tumor variants resistant to antibody-mediated cytotoxicity
Cancer Immunology Immunotherapy, 1982The immunological characteristics of two series of metastatic variants of restricted genetic origin were related to their lung-colony-forming potential. A series of metastatic variants was isolated from a tumor-cell population in which heterogeneity appeared following short-term in vivo passage, while a second series of variants were immunoselected in ...
William C. Davis +2 more
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