Results 71 to 80 of about 905,093 (362)

Regulation of NK cell development and function by cytokines

Frontiers in Immunology, 2013
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais, Sébastien eViel, Morgan eGrau, Thomas eHenry, Jacqueline eMarvel, Thierry eWalzer   +5 more
doaj   +1 more source

Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms

Animals, 2021
Over time, feline viruses have acquired elaborateopportunistic properties, making their infections particularly difficult to prevent and treat. Feline coronavirus (FCoV) and feline herpesvirus-1 (FeHV-1), due to the involvement of host genetic factors ...
Paolo Capozza, Annamaria Pratelli, Michele Camero, Gianvito Lanave, Grazia Greco, Francesco Pellegrini, Maria Tempesta   +6 more
doaj   +1 more source

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry. [PDF]

, 2015
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease affecting mostly children but also adults and characterized by hyperinflammatory features.
Aricò, Maurizio, Biondi, Andrea, Cetica, Valentina, Danesino, Cesare, De Fusco, Carmen, Fagioli, Franca, Griffiths, Gillian M, Locatelli, Franco, Luzzatto, Lucio, Micalizzi, Concetta, Moretta, Lorenzo, Pende, Daniela, Putti, Maria Caterina, Sieni, Elena   +13 more
core   +3 more sources

Immunologic Cytotoxicity in Alopecia Areata: Apoptosis of Dermal Papilla Cells in Alopecia Areata

Journal of Investigative Dermatology, 1995
medium, i.e., that in which confluent dermal papilla cells had been grown for 48 h, was tested for growth-promoting activity on a human skin keratinocyte cell line using an MTT assay. Normal dermal papilla cell medium stimulated keratinocyte growth signif­ icandy at low concentrations compared to control non-conditioned medium but alopecia areata cell ...
Kyu Uang Whang, Marjorie H. Middleton, Richard C. Duke, David A. Nortis   +3 more
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Natural Killer cells and liver fibrosis

Frontiers in Immunology, 2016
In the 40 years since the discovery of Natural Killer (NK) cells it has been well established that these innate lymphocytes are important for early and effective immune responses against transformed cells and infections with different pathogens.
Frank eFasbender, Agata eWidera, Jan G Hengstler, Carsten eWatzl   +3 more
doaj   +1 more source

Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity.

Journal of Immunology, 1991
ICAM-1-mediated cell-cell adhesion is essential for various immunologic functions, including non-MHC-restricted cytotoxicity. The present study was designed to establish whether shedding of ICAM-1 from melanoma cells occurred and to characterize the ...
Jürgen C. Becker, R. Dummer, A. Hartmann, G. Burg, R. Schmidt   +4 more
semanticscholar   +1 more source

Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes

PLOS ONE, 2015
Killing of virally infected cells or tumor cells by cytotoxic T lymphocytes requires targeting of lytic granules to the junction between the CTL and its target. We used whole-cell patch clamp to measure the cell capacitance at fixed intracellular [Ca2+] to study fusion of lytic granules in human CTLs.
Jens Rettig, Ute Becherer, Min Ming, David R. Stevens, Claudia Schirra   +4 more
openaire   +5 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Is there a Role of Intravenous Immunoglobulin in Immunologic Recurrent Pregnancy Loss?

Journal of Immunology Research, 2020
Recurrent pregnancy loss (RPL) commonly refers to three or more miscarriages that occur before 20 weeks of pregnancy. The immunological cause of RPL could be either an auto- or alloimmune-related event or both.
Xiuhua Yang, Tao Meng
doaj   +1 more source