Results 91 to 100 of about 34,355 (311)

IMPACT OF DAPAGLIFLOZIN ON APOPTOSIS AND EFFECTOR CYTOTOXIC CELLS USING BREAST CANCER CELLS IN MICE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Background: Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor with anti-inflammatory, antioxidant, and apoptosis modulator activity.
Shimaa M. Elkhyat, Nageh Elmahdy, Mayada Elhusseiny, Abdel aziz Zidan   +3 more
doaj   +1 more source

3D‐Printable, Biodegradable, and Conductive/Piezoionic Hydrogel ‘E‐Skin’ With Robust Antibacterial Properties for Wound Healing and Wireless Human‐Machine Interface Sensing

Advanced Functional Materials, EarlyView.
A multifunctional MXene‐integrated GelMA/alginate hydrogel reinforced with TEMPO‐modified nanocellulose is engineered via dynamic covalent, ionic, and hydrogen bonding. The resulting piezoelectric, adhesive, antimicrobial, and 3D‐printable patch enables motion sensing and accelerates wound healing by promoting keratinocyte migration and collagen ...
Myoungjoon Jeon, Sayan Deb Dutta, Md. Moniruzzaman, Jeong Man An, Youjin Seol, Gyuhan Son, Sung Ha Jo, Hyun Chang Jung, Beom‐Soo Shin, Jongsung Kim, Yong‐kyu Lee, Ki‐Taek Lim   +11 more
wiley   +1 more source

Effect of SLS-2 spaceflight on immunologic parameters of rats [PDF]

, 1996
During the Spacelab Life Sciences-2 mission, rats were dissected in space and biosamples were returned to Earth for analysis. Immunologic studies addressed the kinetics of T lymphocyte proliferative responses, cytotoxic activity of natural killer cells,
I. Konstantinova, L. Avery, D. Meshkov, A. Lesnyak, M. Rykova, T. Orlova, G. Sonnenfeld   +6 more
core   +1 more source

CD8+ T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types

EBioMedicine, 2015
Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies.
Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, Mark Connors   +17 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Successful kidney transplantation across a positive complement-dependent cytotoxicity crossmatch by using C1q assay-directed, bortezomib-assisted desensitization: A case report. [PDF]

, 2017
RATIONALE: Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients.
김혜진, 정향숙, 박금보래, 정현주, 김유선, 김신영, 박윤희, 김범석, 허규하   +8 more
core   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, EarlyView.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Osteogenic Sarcoma IMMUNOLOGIC PARAMETERS BEFORE AND DURING IMMUNOTHERAPY WITH TUMOR-SPECIFIC TRANSFER FACTOR [PDF]

, 2020
A B S T R A C T 18 patients with osteogenic sarcoma were followed by serial measurements in vitro of tumorspecific cell-mediated cytotoxicity and of "active" and total rosette-forming T-cells.

core  

Effect of Bacterial Lipopolysaccharide Contamination on Gutta Percha- versus Resilon-Induced Human Monocyte Cell Line Toxicity.

Frontiers in Dentistry, 2015
Cytotoxic effects of obturation materials were tested in presence and absence of endotoxin on human monocytes in vitro.Human monocytes from THP-1 cell line were cultured. Three millimeters from the tip of each Resilon and gutta percha points were cut and
Jamshid Hadjati, Hadi Assadian, Abdollah Ghorbanzadeh, Maryam Nourizadeh, Tahereh Fattah, Noushin Shokouhinejad   +5 more
doaj  

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source