Results 101 to 110 of about 34,355 (311)

Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]

, 2006
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core   +1 more source

Macrophage Membrane‐Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1‐ApoE Signaling in Diabetic Wounds

Advanced Healthcare Materials, EarlyView.
Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu, Yuan Xiong, Li Lu, Han Wang, Hui Hu, Mohammad‐Ali Shahbazi, Guohui Liu, Bobin Mi   +7 more
wiley   +1 more source

FIGURE 4 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer [PDF]

scRNA-seq analysis of GD2-2840-CARTs and GD2-CARrejT. A and B, UMAP projection of scRNA-seq data of GD2-2840z-CARTs and GD2-CARrejTs. Cluster gene characteristics determine cluster functional description. Cluster 1: CD4+ T cells/CD8+ T cells 1; Cluster 2:
Takaharu Kimura (18136118), Hiromitsu Nakauchi (18136139), Fumiyuki Takahashi (18136127), Kazutaka Nakashima (16698396), Tomoyuki Yamaguchi (18136121), Shintaro Kinoshita (18136109), Satoshi Yamazaki (18136133), Sakiko Harada (18136124), Koichi Ohshima (16698402), Midori Ishii (18136112), Jun Ando (18136115), Kazuhisa Takahashi (18136136), Miki Ando (18136142), Yozo Nakazawa (18136130)   +13 more
core   +1 more source

Identification of immunological genes important for cytotoxicity [PDF]

, 2019
Natural Killer (NK) cells and Cytotoxic T lymphocytes (CTLs) are essential to defend the body against foreign or transformed cells. An understanding of the mechanism of their cytotoxicity can result in the generation of genetically modified cells with higher cytotoxicity and to identify drug-targets that increase cytotoxicity.
openaire   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Analysis of the Cytotoxic Effects in Removable Dentures Fabricated Using Two Different Processing Techniques: An Observational Comparative Study

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To compare the cytotoxicity of polymethyl methacrylate dentures fabricated through compression molded and injection molded processing techniques.
Hemashree Emayavarman, Kiran Kumar Pandurangan, Anusha Kanniappan Sathiamurthy, Shanmuganathan Natrajan, Kaligotla Apoorva Vasundhara, Maria Maddalena Marrapodi, Marco Cicciù, Giuseppe Minervini   +7 more
doaj  

Immunologic Cytotoxicity in Alopecia Areata: Apoptosis of Dermal Papilla Cells in Alopecia Areata

Journal of Investigative Dermatology, 1995
medium, i.e., that in which confluent dermal papilla cells had been grown for 48 h, was tested for growth-promoting activity on a human skin keratinocyte cell line using an MTT assay. Normal dermal papilla cell medium stimulated keratinocyte growth signif­ icandy at low concentrations compared to control non-conditioned medium but alopecia areata cell ...
Nortis, David A., Duke, Richard, Whang, Kyu, Middleton, Marjorie   +3 more
openaire   +2 more sources

Ambient Light‐Activatable Luminescent Particle‐Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing

Advanced Materials, EarlyView.
We report a wearable photonic patch integrating room light‐ and sunlight‐activatable luminescent particles (RSLPs) for both photochemical tissue bonding and photobiomodulation. RSLPs harvest ambient light and emit red luminescence to drive chlorin e6–mediated collagen crosslinking.
Kyungjoo Jo, Seong‐Jong Kim, Seung Oh Jung, Kyeongtaek Lee, Mungu Kim, Kwanghyeon Park, Yewon Seo, Boram Park, Dongchul Jo, Jongshin Kim, Jin Huh, Hyemin Kim, Sei Kwang Hahn   +12 more
wiley   +1 more source

Lymphocyte activation gene-3 : the expression and function in the immune system [PDF]

, 2006
Lymphocyte activation gene-3 (LAG-3) is the structural homologue of a well-known TCR co-receptor CD4. Recently, it has been suggested that LAG-3 might play a role in modulation of immune response, by being a negative regulator of T cell activation. To
Kisielow, Malgorzata
core   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source