Results 91 to 100 of about 1,578,267 (386)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Calcium Signaling and Cytotoxicity [PDF]

Environmental Health Perspectives, 1999
The divalent calcium cation Ca(2+) is used as a major signaling molecule during cell signal transduction to regulate energy output, cellular metabolism, and phenotype. The basis to the signaling role of Ca(2+) is an intricate network of cellular channels and transporters that allow a low resting concentration of Ca(2+) in the cytosol of the cell ([Ca(2+
George E.N. Kass, Sten Orrenius
openaire   +3 more sources

Design, Synthesis, Anticancer Evaluation and Docking Studies of Novel Heterocyclic Derivatives Obtained via Reactions Involving Curcumin

Molecules, 2018
Curcumin, a widely utilized flavor and coloring agent in food, has been shown to demonstrate powerful antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo.
Rita M. Borik, Nagwa M. Fawzy, Sherifa M. Abu-Bakr, Magdy S. Aly   +3 more
doaj   +1 more source

The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid [PDF]

, 2013
peer-reviewedComplexes of the milk protein, α-lactalbumin, and the fatty acid, oleic acid, have previously been shown to be cytotoxic. Complexes of α-lactalbumin and five different fatty acids (vaccenic, linoleic, palmitoleic, stearic, and elaidic acid ...
Aits, Andrade, Barbana, Brinkmann, Brinkmann, Budavari, Cury, de Lima, Düringer, Fischer, Gustafsson, Gustafsson, Hallgren, Kehoe, Knyazeva, Kohler, Lima, Liskova, Lišková, Mossberg, Mossberg, Mossberg, Nielsen, Permyakov, Permyakov, Pettersson, Pettersson-Kastberg, Rammer, Spolaore, Svanborg, Svensson, Svensson, Tolin, van Engeland, Vukojevic, Wilhelm   +35 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Novel Coumarin-Containing Aminophosphonatesas Antitumor Agent: Synthesis, Cytotoxicity, DNA-Binding and Apoptosis Evaluation

Molecules, 2015
A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) and human lung adenocarcinoma (MGC-803) cell lines in ...
Ya-Jun Li, Cai-Yi Wang, Man-Yi Ye, Gui-Yang Yao, Heng-Shan Wang   +4 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia

Molecules, 2016
Three new2-(2-phenylethyl)chromone derivatives (1–3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl.
Hang Shao, Wen-Li Mei, Wen-Hua Dong, Cui-Juan Gai, Wei Li, Guo-Peng Zhu, Hao-Fu Dai   +6 more
doaj   +1 more source

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity.

Blood, 2019
Chimeric antigen receptor (CAR) T cell therapy has proven effective in relapsed and refractory B cell malignancies, but resistance and relapses still occur.
O. Dufva, J. Koski, Pilvi Maliniemi, Aleksandr Ianevski, J. Klievink, J. Leitner, P. Pölönen, Helena R Hohtari, K. Saeed, T. Hannunen, P. Ellonen, P. Steinberger, M. Kankainen, T. Aittokallio, Mikko A. I. Keränen, M. Korhonen, S. Mustjoki   +16 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source