Results 11 to 20 of about 1,598 (175)

Toxicological Assessment of D-Allulose From a Novel One-Step Fermentation Process Using Genetically Modified Escherichia coli: A 90-Day Dietary Toxicity Study in Rats [PDF]

Journal of Toxicology
D-Allulose is a rare monosaccharide structurally similar to D-fructose, characterized by low caloric content and relatively high sweetness. This study aimed to conduct a 90-day oral toxicity test to systemically evaluate the potential toxicological ...
Zinan Li, Yanmin Nie, Hongju Du, Wenjing Zhang, Shan Zheng, Wenshu Cong, Ying Feng, Guojun Li, Haiming Jing, Junyu Ning, Shan Gao   +10 more
doaj   +3 more sources

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus [PDF]

FEBS Open Bio
d‐Allulose is one of the rare monosaccharides and is considered as a safe ingredient in foods. It can be enzymatically produced from d‐fructose by the enzyme d‐allulose 3‐epimerase.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
doaj   +3 more sources

Growth‐Coupled Evolutionary Pressure Improving Epimerases for D‐Allulose Biosynthesis Using a Biosensor‐Assisted In Vivo Selection Platform [PDF]

Advanced Science
Fast screening strategies that enable high‐throughput evaluation and identification of desired variants from diversified enzyme libraries are crucial to tailoring biocatalysts for the synthesis of D‐allulose, which is currently limited by the poor ...
Chao Li, Xin Gao, Huimin Li, Tong Wang, Fuping Lu, Hui‐Min Qin   +5 more
doaj   +3 more sources

d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes [PDF]

PLoS ONE, 2022
d-allulose is a rare sugar that has been reported to possess anti-hyperglycemic effects. In the present study, we hypothesized that d-allulose is effective in attenuating the progression of diabetic nephropathy in the Otsuka Long-Evans Tokushima Fatty ...
Misato Niibo, Akane Kanasaki, Tetsuo Iida, Keisuke Ohnishi, Taro Ozaki, Kazuya Akimitsu, Tetsuo Minamino   +6 more
doaj   +3 more sources

Metabolically Engineered Escherichia coli for Conversion of D-Fructose to D-Allulose via Phosphorylation-Dephosphorylation [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
D-Allulose is an ultra-low calorie sweetener with broad market prospects. As an alternative to Izumoring, phosphorylation-dephosphorylation is a promising method for D-allulose synthesis due to its high conversion of substrate, which has been ...
Qiang Guo, Chen-Yang Liu, Ling-Jie Zheng, Shang-He Zheng, Ya-Xing Zhang, Su-Ying Zhao, Su-Ying Zhao, Hui-Dong Zheng, Hui-Dong Zheng, Li-Hai Fan, Li-Hai Fan, Xiao-Cheng Lin   +11 more
doaj   +2 more sources

Research Advances of d-allulose: An Overview of Physiological Functions, Enzymatic Biotransformation Technologies, and Production Processes [PDF]

Foods, 2021
d-allulose has a significant application value as a sugar substitute, not only as a food ingredient and dietary supplement, but also with various physiological functions, such as improving insulin resistance, anti-obesity, and regulating glucolipid ...
Yu Xia, Qianqian Cheng, Wanmeng Mu, Xiuyu Hu, Zhen Sun, Yangyu Qiu, Ximing Liu, Zhouping Wang   +7 more
doaj   +2 more sources

Safety of D-allulose as a novel food pursuant to Regulation (EU) 2015/2283. [PDF]

EFSA J
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on D‐allulose as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Cámara M, Bohn T, Castenmiller J, De Henauw S, Jos Á, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Aguilera-Gómez M, Cubadda F, Frenzel T, Heinonen M, Knutsen HK, McArdle HJ, Neuhäuser-Berthold M, Poulsen M, Maradona MP, Schlatter JR, Siskos A, van Loveren H, Multari S, Rossi A, Hirsch-Ernst KI.   +29 more
europepmc   +3 more sources

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats [PDF]

Heliyon, 2021
d-Allulose, a C-3 epimer of d-fructose, is a rare sugar that has no calories. Although d-allulose has been reported to have several health benefits, such as anti-obesity and anti-diabetic effects, there have been no reports evaluating the effects of d ...
Yukie Natsume, Takako Yamada, Tetsuo Iida, Nobuaki Ozaki, Yang Gou, Yoshiharu Oshida, Teruhiko Koike   +6 more
doaj   +2 more sources

Review on D-Allulose: In vivo Metabolism, Catalytic Mechanism, Engineering Strain Construction, Bio-Production Technology

Frontiers in Bioengineering and Biotechnology, 2020
Rare sugar D-allulose as a substitute sweetener is produced through the isomerization of D-fructose by D-tagatose 3-epimerases (DTEases) or D-allulose 3-epimerases (DAEases).
Shaotong Jiang, Peizhou Yang, Zhi Zheng   +2 more
exaly   +3 more sources

Optimization of fermentation conditions for whole cell catalytic synthesis of D-allulose by engineering Escherichia coli [PDF]

Scientific Reports
D-allulose/D-psicose is a significant rare sugar with broad applications in the pharmaceutical, food, and other industries. In this study, we cloned the D-allulose 3-epimerase (DPEase) gene from Arthrobacter globiformis M30, using pET22b as the vector ...
Haoran Liu, Kang Xu, ShuQi Sun, Yinbiao Wan, Bojia Zhang, Yang Song, Chuanzhuang Guo, Songsen Sui, Ruiming Wang, Piwu Li, Junqing Wang, Zhenshang Xu, Ting Wang   +12 more
doaj   +2 more sources