Results 121 to 130 of about 24,218 (173)
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Experimental hepatitis induced by d-galactosamine
Experimental and Molecular Pathology, 1968Abstract Repeated intraperitoneal injections of d -galactosamine produce within 24–48 hours in rat livers alterations that closely resemble human viral hepatitis. Histologic changes include necroses and inflammatory infiltration of periportal areas, mitoses and cell proliferation, the appearance of Councilman bodies, and an increased number of ...
D, Keppler +3 more
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Colchicine prevents d-galactosamine-induced hepatitis
Journal of Hepatology, 1989The hepatoprotective effect of colchicine in a model of liver intoxication with galactosamine (GalN), 375 mg/kg, i.p., was studied in rats. At 0.5, 1, 3, 6, 18 and 24 h after GalN intoxication the following markers of liver damage were measured: serum activity of alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase, hepatic ...
M, Mourelle, M A, Meza
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Gastroprotective effect of vitamin U in D‐galactosamine‐induced hepatotoxicity
Journal of Biochemical and Molecular Toxicology, 2022AbstractGalactosamine (GalN) is a well‐known agent for inducing viral hepatitis models in rodents, but it can cause toxicity on different organs. Vitamin U (Vit U) has been proved as a powerful antioxidant on many toxicity models. The present study was designed to investigate the protective effects of Vit U on GalN‐induced stomach injury.
Dileknur Topaloglu +2 more
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Tryptophan metabolism in D-galactosamine-induced liver injury
Gastroenterologia Japonica, 1988We have reported that in rats with D-galactosamine-induced liver injury, the serum level of indoleacetic acid (IAA), a metabolite of tryptophan (TRP), increases before the increase in serum transaminase activity. To determine whether this IAA is derived from hepatocytes, isolated hepatocytes were treated with D-galactosamine and loaded with TRP, and ...
Y, Mizoguchi +7 more
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Toxicity of d-galactosamine for rat hepatocytes in monolayer culture
Experimental and Molecular Pathology, 1985Hepatocellular injury was induced by exposure of primary cultures of rat hepatocytes to 4 mM D-galactosamine. The cell damage was very similar to that seen in vivo and in the isolated perfused rat liver, both in biochemical and in structural terms.
T A, Tran-Thi +3 more
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Response of Isolated Rat Hepatocytes to D-Galactosamine and Uridine
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1976Isolated rat hepatocytes preserved for several hours their contents of ATP, CTP, GTP, UTP and UDPG. Leakage of intracellular and membrane-bound enzymes remained in the range observed with the isolated perfused rat liver. D-Galactosamine led to a rapid decrease of the UTP and UDPG contents while ATP and GTP levels remained unaffected.
F, Hofmann +3 more
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INduction of tyrosine aminotransferase under the influence of D-galactosamine
International Journal of Biochemistry, 1984The induction of the tyrosine aminotransferase by tyrosine and by tryptophan + methionine is completely inhibited by 375 mg/kg D-galactosamine-HCl. The hydrocortisone induction is reduced in dependence on the amount of D-galactosamine. Tryptophan protects to some extent the influence of low doses of D-galactosamine on the hydrocortisone induction of ...
H, Kröger, R, Grätz
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Hepatotoxicity of d-Galactosamine in the isolated perfused rat liver
Experimental and Molecular Pathology, 1980Abstract The hepatotoxicty of d -galactosamine was evaluated using the isolated perfused rat liver. In controls, ATP- and UDPglucose-levels decreased by about 20% during 12 hr of perfusions; UTP + UDP as well as the energy charge remained constant.
J, Rasenack +4 more
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Effect of d-galactosamine-HCl on the pulmonary surfactant in the rat
Experimental and Molecular Pathology, 1978Abstract Administration of d -galactosamine induced a significant increase in the percentage of serum-free cholesterol and in the phospholipid contents of the pulmonary surfactant in the rat. The maximum change in the surfactant was observed 40 hr after treatment with the drug preceded by the change in serum cholesterol levels.
Y, Suzuki, R, Tabata, K I, Okawa
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A new synthesis of D-galactosamine from D-glucosamine
Journal of the Chemical Society, Perkin Transactions 1, 19722-Amino-2-deoxy-D-galactose was prepared from allyl 2-benzamido-3-O-benzyl-2-deoxy-4,6-di-O-methyl-sulphonyl-β-D-glucopyranoside via allyl 2-benzamido-3-O-benzyl-2-deoxy-β-D-galactopyranoside. The latter compound should prove a suitable intermediate for the preparation of various derivatives of 2-amino-2-deoxy-D-galactose.
P A, Gent, R, Gigg, R, Conant
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