Results 131 to 140 of about 24,218 (173)

D-Galactosamine lethality model: scope and limitations

Journal of Endotoxin Research, 2004
D-Galactosamine (D-galN) is well established as sensitizing mice and other animals to the lethal effects of TNF, specifically, and by several orders of magnitude. Protection by anti-TNF neutralizing antibody is complete, as is (metabolically-based) protection by uridine.
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Prevention of D-galactosamine-induced hepatocellular autophagocytosis by cycloheximide

Virchows Archiv B Cell Pathology, 1974
Application of 500 mg D-galactosamine/kg body weight to rats results in severe hepatocellular injury 10 hours thereafter which includes the appearance of large autophagic vacuoles (focal cytoplasmic degradation) and scattered single cell necroses.
H J, Rumpelt, M, Albring, W, Thoenes
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Cytotoxic effects of exogenous d‐galactosamine on experimental tumors

International Journal of Cancer, 1971
AbstractIn the present work the carcinostatic effect of exogenous D‐galactosamine on Sarcoma‐180 and Ehrlich ascites carcinoma cells was examined in vitro. D‐galactosamine exhibited a powerful anti‐tumor effect on these tumor lines, resulting in a rapid loss of viability and transplantability.
At, arneault G, Walter, L, Bekesi, J G
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Bacterial translocation in d-galactosamine-treated rats in a burn model

Burns, 1996
Bacteria and endotoxins can pass through the gut barrier under certain conditions. This process of bacterial translocation (BT) may occur after thermal injury in animals and is thought to play a role in the pathogenesis of septic complications in severely burned patients.
Dijkstra, HM, Manson, WL, Blaauw, B, Klasen, HJ, deSmet, B   +4 more
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Modification of D-Galactosamine-Induced Liver Injury in the Rat by Spironolactone

Pharmacology, 2008
Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200 mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against the hepatotoxic effect of D-galactosamine (275 mg/kg) in rats ...
A A, Mihas, M M, Foster, S, Barnes, T A, Mihas, B I, Hirschowitz, J G, Spenney   +5 more
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Rat hepatocyte nodules are resistant to the necrogenic effect of D-galactosamine

Carcinogenesis, 1992
D-Galactosamine is a known hepatotoxin which induces liver cell necrosis via depletion of UTP and other uridine nucleotides. Our previous work indicated that nodular hepatocytes have higher levels of total uridine nucleotides compared to normal liver, and in the present study we investigate the effect of galactosamine treatment on hepatocyte nodules ...
LACONI, EZIO, Sarma DS, Pani P.
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Influence of d-galactosamine upon the nad-metabolism in rat liver

International Journal of Biochemistry, 1983
After application of D-galactosamine a hepatitis develops in the rat liver. This can be prevented by different agents, including tryptophan. Yet it has not been possible to give definitive conclusions about the mechanism of galactosamine hepatitis. In this paper we report about the influence of galactosamine on the NAD metabolism.
H, Kröger, R, Grätz, H, Grahn
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Investigations on D-Galactosamine Hepatitis after Pretreatment with alpha-Hexachlorocyclohexane

Beiträge zur Pathologie, 1976
D-Galactosamine hepatitis cannot be induced in rapidly replicating liver tissue at various times after induction of proliferation. Proliferation was induced by administration of alpha-hexachlorocyclohexane. The morphological features of galactosamine hepatitis do not appear or are very mild. The onset of DNA synthesis is delayed to about 12 hrs as also
C, Schuchhardt, W, Reutter, R, Lesch
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Antihyperlipidemic effect of carvacrol on D-galactosamine induced hepatotoxic rats

Journal of Basic and Clinical Physiology and Pharmacology, 2009
Carvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol occuring in many essential oils of the family Labiatae including, Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. The present study was designed to investigate the effect of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity in rats.
Balakrishnan, Aristatile, Khalid S, Al-Numair, Chinnadurai, Veeramani, Kodukkur Viswanathan, Pugalendi   +3 more
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d-Galactosamine hepatotoxicity

Experimental and Molecular Pathology, 1976
Seymour M. Sabesin, Raymond S. Koff
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