Results 81 to 90 of about 720,291 (260)

Sistemática, taxonomía y domesticación de alpacas y llamas: nueva evidencia cromosómica y molecular Systematics, taxonomy and domestication of alpaca and llama: new chromosomal and molecular evidence

Revista Chilena de Historia Natural, 2007
Existen cuatro especies de camélidos sudamericanos, dos de ellos silvestres, guanaco (Lama guanicoe) y vicuña (Vicugna vicugna), y dos formas domésticas, alpaca (Lama pacos) y llama (Lama glama), cuyo origen ha sido objeto de debate.
JUAN C MARÍN, BEATRIZ ZAPATA, BENITO A GONZÁLEZ, CRISTIAN BONACIC, JANE C WHEELER, CIARA CASEY, MICHAEL W BRUFORD, R. EDUARDO PALMA, ELIE POULIN, M. ANGÉLICA ALLIENDE, ÁNGEL E SPOTORNO   +10 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mitochondrial D-loop sequences are integrated in the rat nuclear genome†

Journal of Molecular Biology, 1991
We have cloned two fragments of rat nuclear DNA (nucDNA), 3.3 x 10(3) nucleotide-pairs (knp) and 9.1 knp, that contain a 0.5 knp section sharing 80% sequence identity with the mitochondrial DNA (mtDNA) heavy strand origin of replication (D-loop) nascent strand and 88% identity with each other.
S, Zullo, L C, Sieu, J L, Slightom, H I, Hadler, J M, Eisenstadt   +4 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mitochondrial DNA mutations in women with complete early embryo development arrest in vitro fertilized embryos

陆军军医大学学报
Objective To explore the specific mutations in mitochondrial genes of woman with unexplained complete early embryo development arrest in order to provide new data support for further elucidating the underlying mechanisms. Methods A case-control study was
YAO Xinyi, YAO Xinyi, WANG Wei, WANG Qihang   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Mitochondrial Copy Number and D-Loop Variants in Pompe Patients.

Cell journal, 2016
Pompe disease is a rare neuromuscular genetic disorder and is classified into two forms of early and late-onset. Over the past two decades, mitochondrial abnor- malities have been recognized as an important contributor to an array of neuromuscular diseases.
Bahreini, Fatemeh, Houshmand, Massoud, Modaresi, Mohammad Hossein, Tonekaboni, Hassan, Nafissi, Shahriar, Nazari, Ferdoss, Akrami, Seyed Mohammad   +6 more
openaire   +3 more sources

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source