Results 61 to 70 of about 14,711,288 (261)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
D-Loop Mutation G42A/G46A Decreases Actin Dynamics
Biomolecules, 2020 Depolymerization and polymerization of the actin filament are indispensable in eukaryotes. The DNase I binding loop (D-loop), which forms part of the interface between the subunits in the actin filament, is an intrinsically disordered loop with a large ...
Mizuki Matsuzaki +9 more
doaj +1 more source
Genetic characterization of Atlantic sturgeon stocking material used in Lithuania to restore the Baltic Sea population [PDF]
Acta Ichthyologica et Piscatoria, 2019 Background. Recent genetic analyses of fish remains, obtained from archaeological sites, revealed that more than 2000 years ago the Baltic Sea was inhabited by sturgeons closely related to the Atlantic sturgeon, Acipenser oxyrinchus Mitchill, 1815.
D. Butkauskas +4 more
doaj +3 more sources
One loop phenomenology of type II string theory: intersecting d-branes and noncommutativity [PDF]
, 2007 We examine one loop amplitudes for open and closed strings in certain D-brane configurations, and investigate the consequences for phenomenology. Initially we consider open strings at D6-brane intersections.
Goodsell, Mark Dayvon +1 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
One-loop phenomenology in brane models [PDF]
, 2005 Particular examples of one-loop string effects are explored in the context of brane-based realizations of the Standard Model. We firstly examine the consequences of a phenomenon known as Kinetic Mixing, which couples hidden U(1) gauge factors to visible ...
Schofield, Ben
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core +1 more source