Results 51 to 60 of about 15,206,096 (240)

Synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine –Dendrimer in Wilson’s model cells

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Wilson’s disease (WD) is caused by mutation to the cooer-transporting gene ATP7B. Chelation therapy is the main protochol of treatment for patients with Wilson’s disease.
Fani N, Shafiee Ardestani M, Yaghmaei P, Assadi A, Barzegar Behrouz A   +4 more
doaj  

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Elastosis Perforans Serpiginosa: a D-penicillamine induced dermatoses in a patient with Wilson’s disease

Autopsy and Case Reports, 2021
Long term use of D-penicillamine for Wilson’s disease can be associated with many adverse reactions and systemic side effects. We report the case of a 28-year-old male patient diagnosed with Wilson’s disease presenting with a serpiginous raised ...
Swagatika Samal, Mukund Sable
doaj  

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI

British Journal of Pharmacology, EarlyView.
Background and Purpose Methanobactins are peptides with high copper affinity and potential to treat Wilson disease. We examined how two methanobactins (ARBM101 and MB‐OB3b) affected copper handling in the LPP Atp7b−/− Wilson disease rat model, compared to penicillamine or saline, by 64Cu positron emission tomography/magnetic resonance imaging ...
Emilie Munk Lynderup, Mikkel Holm Vendelbo, Frederik Teicher Kirk, Karina Højrup Vase, Aage Kristian Olsen Alstrup, Tamara Rieder, Alan A. DiSpirito, Jeremy D. Semrau, Tea Lund Laursen, Peter Ott, Hans Zischka, Thomas Damgaard Sandahl   +11 more
wiley   +1 more source

Acute kidney injury and morbi‐mortality associated with “triple whammy” combination: Systematic review and meta‐analysis

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3031-3041, November 2025.
Aims “Triple whammy” (TW) refers to the concomitant use of diuretics, renin‐angiotensin‐aldosterone system inhibitors (RAASI) and non‐steroidal anti‐inflammatory drugs (NSAIDs). The aim of this article is to analyse the association between TW exposure and acute kidney injury (AKI), among other morbi‐mortality outcomes.
Dulce María Calvo, Luis Carlos Saiz, Leire Leache, Maria Concepción Celaya, Marta Gutiérrez‐Valencia   +4 more
wiley   +1 more source

Agreement Between Self‐Reported Antirheumatic Medications and Pharmaceutical Claims in an Australian Inflammatory Arthritis Cohort

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective To assess agreement between prescription claims data and self‐reported medication use via longitudinal questionnaires in the Australian Rheumatology Association Database inflammatory arthritis cohort and to identify predictors of discordant self‐reports.
Tom Lynch, Claire Barrett, Rachel Black, Rachelle Buchbinder, Graeme Carroll, Vibhasha Chand, Catherine L. Hill, Marissa Lassere, Sue Lester, Oscar Russell, Premarani Sinnathurai, Lyn March   +11 more
wiley   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, Volume 12, Issue 40, October 27, 2025.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

An Elegant Method of One‐Pot Ligation‐Desulfurization for High‐Yielding Chemical Protein Synthesis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
A one‐pot native chemical ligation and desulfurization method has been developed for efficient chemical protein synthesis. This unique approach uses bromoacetamide and N‐acetyl cysteine to selectively quench arylthiol post native chemical ligation.
Vishal Malik, Abhisek Kar, Anandh Muthiah Venkatachalam, Kalyaneswar Mandal   +3 more
wiley   +1 more source

Effect of D-penicillamine in prevention of post operative pelvic adhesion formation in rat

Journal of Research in Medical Sciences, 2006
INTRODUCTION: Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications.
Ata-Allah Ghahiri, Elahe Zarean, Mehdi Rasti, Shahriar Adibi   +3 more
doaj  

Sensing of Copper(II) by Immobilized Ligands: Comparison of Electrochemical and Surface Plasmon Resonance Transduction

Proceedings, 2019
Two sensors for the detection of the metal ion Cu(II), based on the same sensing layer, are compared. They rely on different transduction methods, i.e., electrochemistry and surface plasmon resonance (SPR).
Maria Pesavento, Nunzio Cennamo, Raffaela Biesuz, Antonella Profumo, Daniele Merli   +4 more
doaj   +1 more source