Results 101 to 110 of about 15,108,845 (313)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

On the mechanism of Dehydroquinate synthase : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Chemistry [PDF]

, 2001
The aim of this thesis is to investigate the influence of fluorine substitution on the second reaction of the shikimate pathway catalysed by the enzyme 3-dehydroquinate synthase.
Kathirgamanathan, Kalyani
core  

The large-scale organization of metabolic networks [PDF]

, 2000
In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the key role these
Albert, R., Barabasi, A. -L., Jeong, H., Oltvai, Z. N., Tombor, B.   +4 more
core   +3 more sources

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Identification of differential metabolites in liquid diet fermented with Bacillus subtilis using gas chromatography time of flight mass spectrometry

Animal Nutrition, 2016
Growth and health responses of pigs fed fermented liquid diet are not always consistent and causes for this issue are still not very clear. Metabolites produced at different fermentation time points should be one of the most important contributors ...
Yuyong He, Chunxia Mao, Zhiyu Chen, Hong Wen, Wei Lu, Huadong Wu   +5 more
doaj   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Stereoselective formation of a 2 prime (3 prime)- aminoacyl ester of a nucleotide [PDF]

Reaction of DL-series and adenosine-5-phosphorimidazolide in the presence of adenosine-5'-(0-methylphosphate) and imidazole resulted in the stereoselective synthesis of the aminoacyl nucleotide ester, 2'(3')-0-seryl-adenosine-5'-(0-methylphosphate).
Weber, A. L.
core   +1 more source

A Taxonomy of Causality-Based Biological Properties [PDF]

, 2010
We formally characterize a set of causality-based properties of metabolic networks. This set of properties aims at making precise several notions on the production of metabolites, which are familiar in the biologists' terminology.
A. Coletta, A. Phillips, A. Regev, A. Regev, Andrea Bracciali, B. Shargel, B.J. Yu, C. Baral, C. Bodei, C. Bodei, C. Priami, C. Priami, C. Priami, C.H. Schilling, Chiara Bodei, D.A. Fell, Davide Chiarugi, Emanuela Merelli, F. Nielson, F. Nielson, F. Orosz, G.T. Gillespie, H Kitano, H. Kitano, H. Kitano, H. Pilegaard, H. Pilegaard, H. Yu, J. Stelling, J. Thykaer, L. Cardelli, L. Cardelli, M. Curti, N. Chabrier, Paola Quaglia, R. Albert, R. Gori, R. Gori, R. Milner, R.A. Gatenby, R.G. Clyde, Roberta Gori, S. Eker, S. Fatumo, S. Gerdes, S. Klamt, S. Schuster, S. Schuster, S.S Gambhir, U. Alon, V. Danos, V. Danos, Y-K. Oh   +52 more
core   +3 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Medicinal applications of d-ribose l-cysteine in neuro-endocrinopathy, reproductive dysfunction and cardio-metabolic syndrome: A review of evidence in animal investigations

European Journal of Medicinal Chemistry Reports
In recent years, the emergence of d-ribose l-cysteine (DLRC) as a potential treatment regimen for neuro-endocrinopathy, reproductive dysfunction and cardio-metabolic syndrome has been gaining attention among medical professionals.
Oyovwi Mega Obukohwo, Falajiki Yewande Faith, Ohwin Peggy Ejiro, Mok Mishael Onyebuchi, Ayodeji Folorunsho Ajayi   +4 more
doaj   +1 more source