Potential Clinical Benefits of D-ribose in Ischemic Cardiovascular Disease. [PDF]
Cureus, 2018 Cardiovascular disease still remains the leading cause of deaths worldwide. Atherosclerosis, the most common type of cardiovascular disease, has continued to progress due to many factors, genetics, and lifestyles.
Shecterle LM, Terry KR, St Cyr JA.
europepmc +2 more sources
Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]
, 2007 Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J. +11 more
core
Williamsia faeni sp. nov., an actinomycete isolated from a hay meadow [PDF]
, 2010 The taxonomic status of an actinomycete isolated from soil collected from a hay meadow was determined using a polyphasic approach. The strain, designated N1350T, had morphological and chemotaxonomic properties consistent with its classification in the ...
Goodfellow, Michael +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Functional cartography of complex metabolic networks
, 2005 High-throughput techniques are leading to an explosive growth in the size of biological databases and creating the opportunity to revolutionize our understanding of life and disease.
A Arenas +29 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Virtual Screening of Small Molecular Inhibitors against DprE1
Molecules, 2018 Decaprenylphosphoryl-β-d-ribose oxidase (DprE1) is the flavoprotein subunit of decaprenylphosphoryl-d-ribose epimerase involved in cell wall synthesis in Mycobacterium tuberculosis and catalyzes the conversion of decaprenylphosphoryl ribose to ...
Gang Zhang +3 more
doaj +1 more source
Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational Stability. [PDF]
PLoS ONE, 2016 Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we have targeted several conserved amino acids for mutational analysis (i.e. Cys69, His11, His102,
Preet Kamal Kaur +6 more
doaj +1 more source
Hypoglycemic Effect of D-Ribose in Man
Experimental Biology and Medicine, 1957 SummaryInfusion of D-ribose into normal man causes a marked decrease in blood glucose level which is not associated with significant elevation of blood pyruvate level or large decreases in serum inorganic phosphate concentration. Though the exact mechanism of this hypoglycemia is obscure the data appear to exclude increased peripheral glucose ...
S, SEGAL, J, FOLEY, J B, WYNGAARDEN
openaire +2 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source