Results 61 to 70 of about 15,108,845 (313)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Characterization of a d-lyxose isomerase from Bacillus velezensis and its application for the production of d-mannose and l-ribose

AMB Express, 2019
d-Mannose and l-ribose are two important monosaccharides, which have attracted public attention recently because of their great application potentials in food, cosmetic and pharmaceutical industries.
Zongren Guo, Liangkun Long, Shaojun Ding
doaj   +1 more source

Citricoccus parietis sp. nov., isolated from a mould-colonized wall and emended description of Citricoccus alkalitolerans Li et al. 2005 [PDF]

, 2009
A Gram-positive, coccoid-shaped organism (strain 02-Je-010T), forming yellow-pigmented colonies was isolated from the wall of an indoor environment. On the basis of 16S rRNA gene sequence similarity studies, it was shown that strain 02-Je-010T belongs to
Kämpfer, Peter, Martin, Karin, Schäfer, Jenny   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine [PDF]

, 2013
Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM-ether directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as ...
Abraham E., Ahmed M. Zaed, Ait-Youcef R., Allepuz A. C., Amarante G. W., Andrew Sutherland, Barrett A. G. M., Bernet B., Blanchette M. A., Cai Y., Cai Y., Chen B.-S., Cook G. R., Corey E. J., Corey E. J., Cuadros R., Davies S. G., Devi T. J., Dickson R. C., Dinda S. K., Enders D., Ewen D. D. Calder, Fanning K. N., Fernandes R. A., Ghosal P., Hertweck C., Hoffmann R. W., Howell A. R., Hubieki M. P., Jamieson A. G., Jamieson A. G., Jamieson A. G., Jamieson A. G., Kokatla H. P., Kolb H. C., Kolter T., Koskinen P. M., Lee S. I., Lipshutz B. H., Liu Z., Llaveria J., Lombardo M., Luo S.-Y., Malik G., Martinková M., Modrak D. E., Morales-Serna J. A., Murakami T., Naidu S. V., Ndakala A. J., Ndonye R. M., Perali R. S., Prabhakar P., Rodriguez-Lafrasse C., Schneiter R., Sengupta S., Snook C. F., So R. C., Summers S. A., Swift M. D., Séguin C., Watanabe M., Xarnod C., Xu K., Yoon H. J., Yun J. M., Zaed A., Zaed A. M.   +67 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761) [PDF]

, 2006
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue.
Eckert, Anne, Kreßmann, Sabine, Leutner, Silke, Müller, Walter E., Schindowski, Katharina   +4 more
core  

How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases [PDF]

, 2016
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular
Breit, Claudia, Clarke, Mitchell, Etchandy, Guillermina, Mohammad, Mohammad A., Pickwell, Sage, Rodriguez-Teja, Mercedes, Stasiuk, Graeme J., Sturge, Justin, Talar, Kamil, Wang, Kai   +9 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Synthesis of 1-epihydantocidin from d-ribose

Tetrahedron Letters, 1993
Abstract A key step in a short synthesis of 1- epi hydantocidin (2) is the unanticipated transformation of azidolactones (8) and (10) to a bicyclic amine (12) induced by tetra- n -propylammonium perruthenate in the presence of morpholine-N-oxide. The structure of (12) was established by X-ray crystallographic analysis.
Fairbanks, A, Ford, P, Watkin, D, Fleet, G   +3 more
openaire   +1 more source