Results 141 to 150 of about 15,108,845 (313)

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Analysis of volatile compounds, α-dicarbonyl compounds, and acetic acid in Robusta coffee by soaking with D-xylose and D-ribose

Chemical and Biological Technologies in Agriculture
Background The study investigated the impact of D-xylose and D-ribose soaking methods (autoclaved and non-autoclaved) on Robusta coffee's volatile compounds, α-dicarbonyl compounds (α-DCs), and acetic acid. Robusta coffees were soaked with D-xylose and D-
Jooyeon Park, Eunyeong Choi, Kwang-Geun Lee   +2 more
doaj   +1 more source

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Reaction-noise induced homochirality

, 2006
Starting from the chemical master equation, we employ field theoretic techniques to derive Langevin-type equations that exactly describe the stochastic dynamics of the Frank chiral amplification model with spatial diffusion.
Amit, Avalos, Avalos, Avetisov, Buhse, David Hochberg, Doi, Epstein, Frank, Gutman, Hochberg, Howard, Kondepudi, María-Paz Zorzano, Mason, Peliti, Rivera Islas, Todorović, Täuber   +18 more
core   +1 more source

Synthesis of rare sugars via epimerization catalyzed by tin-organic frameworks

Current Research in Green and Sustainable Chemistry
Epimerization of readily available monosaccharides presents an atom-efficient approach to expand the portfolio of rare monosaccharides. Here, we report tin-organic frameworks (Sn-OF) as a highly selective catalyst for synthesis of rare monosaccharides ...
Valérie Toussaint, Theresa Röper, Katarina Hricova, Irina Delidovich   +3 more
doaj   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

D-Ribose-Induced Glycation and Its Attenuation by the Aqueous Extract of Nigella sativa Seeds. [PDF]

Medicina (Kaunas), 2022
Balyan P, Ola MS, Alhomida AS, Ali A.
europepmc   +1 more source

Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview

European Journal of Organic Chemistry, EarlyView.
This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley   +1 more source

Antioxidant Activity and Inhibition of Carbohydrate Hydrolyzing Enzymes by Underutilized Parts From Some Plant‐Based Foods and Their Effect on Postprandial Hyperglycemia

Food Chemistry International, EarlyView.
The underutilized parts viz: pawpaw seed, banana, plantain, and potato peels showed promising antioxidant and inhibition of α‐amylase and α‐glucosidase activities (IC50 values ≤ 100 μg/mL). Similarly, pawpaw seed, banana, plantain, and potato peels reduced postprandial hyperglycemia in sucrose‐ and maltose‐induced hyperglycemia in rats.
Aminu Mohammed, Buhari Shehu Saidu, Nuhu Aliyu, Michael Peter Simon   +3 more
wiley   +1 more source

Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Antioxidants
Selenosugars are gaining growing interest due to their antioxidant efficacy, and their ability to inhibit glycosidases, repair skin tissue or reduce endothelial dysfunction.
Giovanna Cimmino, Mauro De Nisco, Simona Piccolella, Claudia Gravina, Silvana Pedatella, Severina Pacifico   +5 more
doaj   +1 more source