Identification of hydantoin based Decaprenylphosphoryl-β-D-Ribose Oxidase (DprE1) inhibitors as antimycobacterial agents using computational tools. [PDF]
Sci Rep, 2022 Tuberculosis (TB) is one of the emerging infectious diseases in the world. DprE1 (Decaprenylphosphoryl-β-d-ribose 2′-epimerase), an enzyme accountable for mycobacterial cell wall synthesis was the first drug gable target based on discoveries of ...
Mali SN +3 more
europepmc +2 more sources
Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction. [PDF]
Am J Cardiol, 2022 Patients with heart failure with preserved ejection fraction (HFpEF) have few pharmacologic therapies, and it is not known if supplementing with ubiquinol and/or d-ribose could improve outcomes.
Pierce JD +9 more
europepmc +2 more sources
Mitochondrial bioenergetics and D-ribose in HFpEF: a brief narrative review. [PDF]
Ann Transl Med, 2021 Objective In this review article, we briefly describe the status of treatment options for HFpEF and the role of mitochondrial dysfunction in the pathogenesis of HFpEF as an alternative therapeutic target.
Krueger KJ +5 more
europepmc +2 more sources
Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice. [PDF]
Transl Psychiatry, 2021 The effects of different forms of monosaccharides on the brain remain unclear, though neuropsychiatric disorders undergo changes in glucose metabolism. This study assessed cell viability responses to five commonly consumed monosaccharides—D-ribose (RIB),
Xu K +5 more
europepmc +2 more sources
Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart [PDF]
, 2013 Background: Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Aksentijevic, Dunja +6 more
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Chiral Recognition of D/L-Ribose by Visual and SERS Assessments
Molecules, 2023 Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules.
Guohua Yao +3 more
doaj +1 more source
D-ribose induces cellular protein glycation and impairs mouse spatial cognition. [PDF]
PLoS ONE, 2011 BACKGROUND: D-ribose, an important reducing monosaccharide, is highly active in the glycation of proteins, and results in the rapid production of advanced glycation end products (AGEs) in vitro.
Chanshuai Han +4 more
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D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. [PDF]
Aging (Albany NY), 2019 Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear.
Yu L, Chen Y, Xu Y, He T, Wei Y, He R.
europepmc +2 more sources
Protective Effects of Kaempferol on D-Ribose-Induced Mesangial Cell Injury. [PDF]
Oxid Med Cell Longev, 2019 Recently, it has been found that the level of urinary D-ribose in type 2 diabetes is notably higher than that in age-matched normal control, and D-ribose is more reactive in the glycation than D-glucose and induces oxidative stress.
Zhang N, Zhao S, Hong J, Li W, Wang X.
europepmc +2 more sources
Shipin gongye ke-ji, 2022 Study the effects of aerobic exercise combined with D-ribose supplementation on the anti-fatigue and antioxidant enzyme activities of mice, the mice were divided into quiet control group, aerobic exercise control group, D-ribose control group, D-ribose ...
Zhengang ZHANG, Feng WANG
doaj +1 more source