Results 101 to 110 of about 544,097 (279)
Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]
, 2013 Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Castaldo, C +6 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Mouse d-Amino-Acid Oxidase: Distribution and Physiological Substrates
Frontiers in Molecular Biosciences, 2017 d-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of d-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO.
Reiko Koga +4 more
doaj +1 more source
Hans Journal of Biomedicine, 2013 D-丝氨酸主要存在于哺乳动物的前脑，海马区和纹状体，作为胶质细胞释放的神经递质，作用于NMDA (N-methyl-D-aspartate receptor)受体，引起中枢神经系统中信号的传导。在突触可塑性，学习和记忆等方面起重要作用。丝氨酸消旋酶是一种磷酸吡多醛依赖酶，在ATP和Mg2+的辅助下，通过消旋作用将L型丝氨酸转变为D型丝氨酸。对于神经及精神性疾病，丝氨酸消旋酶可能是一个新的治疗靶点。本文从D-丝氨酸和丝氨酸消旋酶的结构性质，作用机理，功能，调控等方面进行了阐述。 D-serine mainly distributed in the mammalian forebrain, hippocampus and striatum, which as neurotransmit-ters ...
openaire +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine
Frontiers in Synaptic Neuroscience, 2014 D-amino acid oxidase (DAO, DAAO) degrades the NMDA receptor co-agonist D-serine, modulating D-serine levels and thence NMDA receptor function. DAO inhibitors are under development as a therapy for schizophrenia, a disorder involving both NMDA receptor ...
Jill F. Betts +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
The Role of APP in Structural Spine Plasticity
Frontiers in Molecular Neuroscience, 2017 Amyloid precursor protein (APP) is a transmembrane protein highly expressed in neurons. The full-length protein has cell-adhesion and receptor-like properties, which play roles in synapse formation and stability.
Elena Montagna +4 more
doaj +1 more source
From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli [PDF]
, 2015 Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to intestinal cells using a dedicated type III secretion system (T3SS). This complex multi-protein organelle is encoded within a large pathogenicity island called the
Connolly, J.P., Finlay, B.B., Roe, A.J.
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source