Results 111 to 120 of about 14,981,197 (293)

Pseudoenantiomeric oxetane delta-amino acid scaffolds derived from L-rhamnose and D-xylose: D/L-alanine-D-serine and glycine-L-serine dipeptide isosteres

, 2016
A series of oxetane δ-amino acid scaffolds derived from L-rhamnose and D-xylose provide a new class of templated sugar amino acids (SAA), which can be considered as D/L-alanine-D-serine and glycine-L-serine dipeptide isosteres. © 2004 Elsevier Ltd.

core   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

D-serine Is a Gliotransmitter or Neurotransmitter

, 2023
D-Serine, a co-agonist of NMDA receptors has sparked a contentious debate within the scientific community regarding its status as a gliotransmitter or a neurotransmitter. This comprehensive review delves into the heart of this debate, offering a meticulous analysis of the existing evidence from various research methodologies. Immunostaining studies and
openaire   +1 more source

D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period [PDF]

, 2016
N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist.
Muriel Amar, Claire N. J. Meunier (2579599), Fossier, Philippe, Loredano Pollegioni, Claire N J Meunier, Philippe Fossier (703126), Le Roux, Nicolas, Meunier, Claire N. J, Mothet, Jean Pierre, Grégoire Levasseur (203854), Silvia Sacchi, Mothet, Jean-Pierre, Amar, Muriel, Glenn Dallérac (2579593), Dallérac, Glenn, Levasseur, Grégoire, Grégoire Levasseur, Loredano Pollegioni (431558), Jean-Pierre Mothet, POLLEGIONI, LOREDANO, SACCHI, SILVIA, Nicolas Le Roux, Meunier, Claire Nicole-Jeanne, Muriel Amar (2579605), Philippe Fossier, Nicolas Le Roux (2579602), Jean-Pierre Mothet (2579608), Glenn Dallérac, Silvia Sacchi (2579596)   +28 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. [PDF]

, 2013
International audienceGlial cells are increasingly recognized as active players that profoundly influence neuronal synaptic transmission by specialized signaling pathways.
Gasnier, B., Jahn, R., Klingauf, Jürgen, Mothet, J.P., Shi, Ting, Sweedler, J.V., Dulong, Jérôme, Martineau, Magalie, Knolhoff, Ann M, Jahn, Reinhard, Gasnier, Bruno, Dulong, J., Klingauf, J., Puyal, Julien, Mothet, Jean-Pierre, Martineau, M., Mothet, J., Shi, T., Sweedler, Jonathan V, Puyal, J., Knolhoff, A., Sweedler, J., Knolhoff, A.M.   +22 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia

Heliyon
Background: Several hypotheses regarding the pathomechanisms of schizophrenia have been proposed. If schizophrenia is a unitary disease, then these pathological processes must be linked; however, if such links do not exist, schizophrenia may best be ...
Yoshiaki Isomura, Mikiko Ohno, Satoshi Sudo, Mayuko Ono, Yuki Kaminishi, Yukiyoshi Sumi, Atsushi Yoshimura, Kumiko Fujii, Kazufumi Akiyama, Eiichiro Nishi, Yuji Ozeki   +10 more
doaj   +1 more source

Serine racemase expression and brain D-serine levels in transgenic mice.

, 2013
(A) Schematic representation of the construct for serine racemase overexpression in glial cells under a GFAP promoter. The GFAP promoter is represented as a black line, the serine racemase ORF as a black bar and the SV40 intron/polyA signal as a grey bar.
Haang Jeung (425208), Andras Bilkei-Gorzo (425205), David-Marian Otte (425203), Maria Luisa Barcena de Arellano (425204), Judith Alferink (425209), Önder Albayram (425206), Sophie Imbeault (425207), Andreas Zimmer (78836)   +7 more
core   +1 more source