Results 131 to 140 of about 10,883,538 (292)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

D-Serine and Serine Racemase

Hans Journal of Biomedicine, 2013
D-丝氨酸主要存在于哺乳动物的前脑，海马区和纹状体，作为胶质细胞释放的神经递质，作用于NMDA (N-methyl-D-aspartate receptor)受体，引起中枢神经系统中信号的传导。在突触可塑性，学习和记忆等方面起重要作用。丝氨酸消旋酶是一种磷酸吡多醛依赖酶，在ATP和Mg2+的辅助下，通过消旋作用将L型丝氨酸转变为D型丝氨酸。对于神经及精神性疾病，丝氨酸消旋酶可能是一个新的治疗靶点。本文从D-丝氨酸和丝氨酸消旋酶的结构性质，作用机理，功能，调控等方面进行了阐述。 D-serine mainly distributed in the mammalian forebrain, hippocampus and striatum, which as neurotransmit-ters ...
openaire   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Serine racemase expression and brain D-serine levels in transgenic mice.

, 2013
(A) Schematic representation of the construct for serine racemase overexpression in glial cells under a GFAP promoter. The GFAP promoter is represented as a black line, the serine racemase ORF as a black bar and the SV40 intron/polyA signal as a grey bar.
Haang Jeung (425208), Andras Bilkei-Gorzo (425205), David-Marian Otte (425203), Maria Luisa Barcena de Arellano (425204), Judith Alferink (425209), Önder Albayram (425206), Sophie Imbeault (425207), Andreas Zimmer (78836)   +7 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

IRI inverts D−/L-serine ratio in urine.

, 2014
Urinary serine enantiomers were analyzed using 2D-HPLC. (A) Typical chromatograms showing urinary D−/L-serine in C57BL/6J wild-type mice with or without renal IRI. (B-G) Concentrations of D-serine (B), L-serine (C), creatinine (D), KIM-1 (F), and NGAL (G)
Sonomi Ito (516633), Chieko Okamura (516632), Masashi Mita (516635), Kenji Hamase (516636), Sadakazu Aiso (424134), Masataka Suzuki (516629), Ryuichi Konno (516634), Jumpei Sasabe (516628), Yurika Miyoshi (516630), Yosuke Tojo (516631)   +9 more
core   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

d-Serine’s Journey Between Stars and Synapses

Neurochemical Research
Abstract Astrocytes play a pivotal role in regulating synaptic transmission, with d -serine emerging as a key gliotransmitter shaping NMDA receptor-dependent functions.
Sarah Mountadem, Stéphane Henri Richard Oliet, Aude Panatier   +2 more
openaire   +2 more sources

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source