Results 121 to 130 of about 14,981,197 (293)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Roles of serine in neurodegenerative diseases

EXCLI Journal : Experimental and Clinical Sciences, 2023
Jia-Meng Li, Shuang-Qing Zhang
doaj   +1 more source

D-Serine metabolism: New insights into the modulation of d-amino acid oxidase activity

, 2013
Over the years, accumulating evidence has indicated that d-serine represents the main endogenous ligand of NMDA (N-methyl-d-aspartate) receptors. In the brain, the concentration of d-serine stored in cells is defined by the activity of two enzymes ...
Sacchi S.
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Renal IRI increases D-serine and reduces L-serine in mouse serum.

, 2014
(A) Shown are typical chromatograms of serum D−/L-serine obtained by 2D-HPLC. [Mice with sham-op (Sham); and those at 4, 8, 20, and 40 h after renal IRI (IRI 4, IRI 8, IRI 20, and IRI 40)] (B-F) Concentrations of serum D-serine (B), L-serine (C ...
Sonomi Ito (516633), Chieko Okamura (516632), Masashi Mita (516635), Kenji Hamase (516636), Sadakazu Aiso (424134), Masataka Suzuki (516629), Ryuichi Konno (516634), Jumpei Sasabe (516628), Yurika Miyoshi (516630), Yosuke Tojo (516631)   +9 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Brain D-serine levels and behavior of Wt mice after D-serine administration.

, 2013
(A) Quantitative analysis of brain D-serine and L-serine levels per wet weight in 4–8 dietary-treated Wt mice by HPLC. D-serine levels of cortex, hippocampus and forebrain were measured.
Haang Jeung (425208), Andras Bilkei-Gorzo (425205), David-Marian Otte (425203), Maria Luisa Barcena de Arellano (425204), Judith Alferink (425209), Önder Albayram (425206), Sophie Imbeault (425207), Andreas Zimmer (78836)   +7 more
core   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

, 1997
d-Serine is localized in mammalian brain to a discrete population of glial cells near NMDA receptors, suggesting thatd-serine is an endogenous agonist of the receptor-associated glycine site.
Michael J. Schell, Mark E. Molliver, Roscoe O. Brady Jr., Solomon H. Snyder   +3 more
core   +1 more source